What the FDA labels say about taking them together
Amphetamine and protriptyline
Amphetamine's FDA label of August 20, 2026 names protriptyline in its drug interactions section; the protriptyline label PlainMeds reads does not name amphetamine. The amphetamine label: “Antidepressants tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained …”
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC).
What does the amphetamine label say about protriptyline?
Amphetamine label, drug interactionsAntidepressants tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d- amphetamine in the brain; cardiovascular effects can be potentiated.
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the protriptyline label say about amphetamine?
Protriptyline's label (effective July 25, 2023) does not name amphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Protriptyline | |
|---|---|---|
| Labeled for | ADHD | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | $2.71 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once