What the FDA labels say about taking them together
Amoxicillin and esomeprazole
Esomeprazole's FDA label of March 19, 2024 names amoxicillin in its contraindications (prescription label) section; the amoxicillin labels PlainMeds reads (2) do not name esomeprazole. The esomeprazole label: “Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Amoxicillin also has drug interactions.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC).
What does the amoxicillin label say about esomeprazole?
Amoxicillin's label (effective February 22, 2024) and its 1 other brand-application label do not name esomeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the esomeprazole label say about amoxicillin?
Esomeprazole label, contraindications (prescription label)For information about contraindications of amoxicillin and clarithromycin, indicated in combination with NEXIUM for H. pylori eradication to reduce the risk of duodenal ulcer recurrence, refer to the Contraindications section of the respective prescribing information.
Esomeprazole label, drug interactions (prescription label)Combination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Amoxicillin also has drug interactions. Intervention: See Contraindications, Warnings and Precautions in prescribing information for clarithromycin. See Drug Interactions in prescribing information for amoxicillin.
Esomeprazole label, warnings and precautions (prescription label)For more information specific to antibacterial agents (clarithromycin and amoxicillin) indicated for use in combination with NEXIUM, refer to Warnings and Precautions section of the corresponding prescribing information.
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), contraindicationsFor information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with esomeprazole strontium, refer to the CONTRAINDICATIONS section of their package inserts.
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), drug interactionsDrug interaction studies have shown that esomeprazole does not have any clinically significant interactions with phenytoin, quinidine, clarithromycin, or amoxicillin.
Source: FDA drug label (Esomeprazole Strontium, NDA202342), R2 Pharma, LLC, effective September 22, 2016 (SPL set 3c916d32-f9e9-1d15-e054-00144ff88e88), via openFDA
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Esomeprazole | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $0.145 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once