What the FDA labels say about taking them together
Amlodipine and cobicistat
Cobicistat's FDA label of February 10, 2026 names amlodipine in its drug interactions section; the amlodipine labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “Clinical monitoring is recommended for coadministration with calcium channel blockers metabolized by CYP3A.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the amlodipine label say about cobicistat?
Amlodipine's label (effective February 15, 2023) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the cobicistat label say about amlodipine?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Calcium Channel Blockers: e.g., amlodipine diltiazem felodipine nifedipine verapamil; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ calcium channel blockers; Clinical Comment: Clinical monitoring is recommended for coadministration with calcium channel blockers metabolized by CYP3A.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amlodipine | Cobicistat | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once