What the FDA labels say about taking them together
Amiodarone and vardenafil
Vardenafil's FDA label of January 5, 2026 names amiodarone in its warnings and precautions section; the amiodarone labels PlainMeds reads (2) do not name vardenafil. The vardenafil label: “Patients taking Class 1A or Class III antiarrhythmic medications or those with congenital QT prolongation, should avoid using vardenafil.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the vardenafil FDA label on DailyMed (effective January 5, 2026, Zydus Pharmaceuticals USA Inc.).
What does the amiodarone label say about vardenafil?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name vardenafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the vardenafil label say about amiodarone?
Vardenafil label, warnings and precautionsPatients taking Class 1A (for example. quinidine, procainamide) or Class III (for example, amiodarone, sotalol) antiarrhythmic medications or those with congenital QT prolongation, should avoid using vardenafil.
Source: FDA drug label (VARDENAFIL), Zydus Pharmaceuticals USA Inc., effective January 5, 2026 (SPL set 5876e062-e604-42a7-99c3-5da30b8dac06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Vardenafil | |
|---|---|---|
| Labeled for | n/a | Erectile dysfunction |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $2.79 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once