What the FDA labels say about taking them together
Amiodarone and siponimod
Siponimod's FDA label of June 30, 2026 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name siponimod.
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the siponimod FDA label on DailyMed (effective June 30, 2026, Novartis Pharmaceuticals Corporation).
What does the amiodarone label say about siponimod?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name siponimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the siponimod label say about amiodarone?
Siponimod label, drug interactionsClass Ia (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) antiarrhythmic drugs have been associated with cases of Torsades de Pointes in patients with bradycardia.
Source: FDA drug label (MAYZENT), Novartis Pharmaceuticals Corporation, effective June 30, 2026 (SPL set 44492772-5aed-4627-bd85-e8e89f308bb3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Siponimod | |
|---|---|---|
| Labeled for | n/a | Multiple sclerosis |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once