What the FDA labels say about taking them together
Amiodarone and ponesimod
Ponesimod's FDA label of December 4, 2025 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name ponesimod.
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the ponesimod FDA label on DailyMed (effective December 4, 2025, Vanda Pharmaceuticals Inc.).
What does the amiodarone label say about ponesimod?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name ponesimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the ponesimod label say about amiodarone?
Ponesimod label, drug interactionsClass Ia (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) anti-arrhythmic drugs have been associated with cases of Torsades de Pointes in patients with bradycardia.
Source: FDA drug label (PONVORY), Vanda Pharmaceuticals Inc., effective December 4, 2025 (SPL set 0c025ba8-ba51-272e-e063-6294a90ad120), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Ponesimod | |
|---|---|---|
| Labeled for | n/a | Multiple sclerosis |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once