What the FDA labels say about taking them together
Amiodarone and orlistat
Orlistat's FDA label of March 18, 2026 names amiodarone in its drug interactions (prescription label) section; the amiodarone labels PlainMeds reads (2) do not name orlistat. The orlistat label: “A reduction in exposure to amiodarone was observed when XENICAL was co-administered.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the orlistat FDA label on DailyMed (effective March 18, 2026, Haleon US Holdings LLC).
What does the amiodarone label say about orlistat?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name orlistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the orlistat label say about amiodarone?
Orlistat label, drug interactions (prescription label)A reduction in exposure to amiodarone was observed when XENICAL was co-administered.
Orlistat label, warnings and precautions (prescription label)Interactions and Decreased Vitamin Absorption XENICAL may interact with concomitant drugs including cyclosporine, levothyroxine, warfarin, amiodarone, antiepileptic drugs, and antiretroviral drugs [see Drug Interactions (7) ].
Orlistat label, warningsSome prescription doses may need to be adjusted, or some medications may not work as well when used with orlistat. anticoagulants (blood thinning medicine) amiodarone (heart medicine) diabetes medicine thyroid disease medicine seizure medicine antiretrovirals (HIV medicine) taking any other weight loss products When using this product take a multivitamin once a day, at bedtime.
Source: FDA drug label (ALLI), Haleon US Holdings LLC, effective March 18, 2026 (SPL set a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Orlistat | |
|---|---|---|
| Labeled for | n/a | Weight management |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $7.00 per capsule 120 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once