What the FDA labels say about taking them together
Amiodarone and lidocaine
Amiodarone's FDA label of December 9, 2025 names lidocaine in its drug interactions section, and lidocaine's label names amiodarone too. The amiodarone label: “CYP3A Substrate lidocaine Sinus bradycardia has been reported with oral amiodarone in combination with lidocaine given for local anesthesia. Monitor heart rate.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC).
What does the amiodarone label say about lidocaine?
Amiodarone label, drug interactionsCYP3A Substrate lidocaine Sinus bradycardia has been reported with oral amiodarone in combination with lidocaine given for local anesthesia. Monitor heart rate.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the lidocaine label say about amiodarone?
Lidocaine Hydrochloride And Dextrose label (Baxter Healthcare Corporation, February 20, 2026), drug interactionsWhen lidocaine is administered with other antiarrhythmic drugs such as amiodarone, phenytoin, procainamide, propranolol or quinidine, the cardiac effects may be additive or antagonistic and toxic effects may be additive.
Source: FDA drug label (Lidocaine Hydrochloride And Dextrose, NDA018461), Baxter Healthcare Corporation, effective February 20, 2026 (SPL set f21512ea-c7c3-4766-b976-b2c0b5616bf0), via openFDA
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Lidocaine | |
|---|---|---|
| Labeled for | n/a | Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.154 per gram 5% ointment |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once