What the FDA labels say about taking them together
Amiodarone and letermovir
Letermovir's FDA label of January 14, 2026 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name letermovir. The letermovir label: “Close clinical monitoring for adverse events related to amiodarone is recommended during co-administration. Frequently monitor amiodarone concentrations when amiodarone is co-administered with PREVYMIS.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the letermovir FDA label on DailyMed (effective January 14, 2026, Merck Sharp & Dohme LLC).
What does the amiodarone label say about letermovir?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name letermovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the letermovir label say about amiodarone?
Letermovir label, drug interactionsConcomitant Drug Class and/or Clearance Pathway/Drug Name: amiodarone; Effect on Concentration ↓ =decrease, ↑ =increase: ↑ amiodarone; Clinical Comments: Close clinical monitoring for adverse events related to amiodarone is recommended during co-administration. Frequently monitor amiodarone concentrations when amiodarone is co-administered with PREVYMIS.
Source: FDA drug label (PREVYMIS), Merck Sharp & Dohme LLC, effective January 14, 2026 (SPL set 1b49df80-be4f-47e0-a0b7-123f3e69395b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Letermovir | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once