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What the FDA labels say about taking them together

Amiodarone and eliglustat

Eliglustat's FDA label of March 3, 2024 names amiodarone in its warnings and precautions section; the amiodarone labels PlainMeds reads (2) do not name eliglustat. The eliglustat label: “Avoid use of CERDELGA in patients with: pre-existing cardiac disease long QT syndrome in combination with Class IA or Class III antiarrhythmic medications”

Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the eliglustat FDA label on DailyMed (effective March 3, 2024, Genzyme Corporation).

What does the amiodarone label say about eliglustat?

Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name eliglustat in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed

What does the eliglustat label say about amiodarone?

Eliglustat label, warnings and precautions

Avoid use of CERDELGA in patients with: pre-existing cardiac disease (congestive heart failure, recent acute myocardial infarction, bradycardia, heart block, ventricular arrhythmia) long QT syndrome in combination with Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications [see Clinical Pharmacology (12.2) ]

Source: FDA drug label (Cerdelga), Genzyme Corporation, effective March 3, 2024 (SPL set 819f828a-b888-4e46-83fc-94d774a28a83), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

32Amiodarone generic labelers
0Eliglustat generic labelers
AmiodaroneEliglustat
Labeled forn/an/a
Boxed warningYesNo
Pharmacy cost (NADAC)$0.122 per tablet 200 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?