What the FDA labels say about taking them together
Amiodarone and cimetidine
Amiodarone's FDA label of December 9, 2025 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name amiodarone. The amiodarone label: “Increased exposure of amiodarone. Avoid concomitant use.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the amiodarone label say about cimetidine?
Amiodarone label, drug interactionsConcomitant Drug/Class/Name: CYP450 Inhibitors; Examples: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors; Clinical Comment: Increased exposure of amiodarone. Avoid concomitant use.
Source: FDA drug label (Nexterone, NDA022325), Baxter Healthcare Corporation, effective April 16, 2024 (SPL set e9108958-b8d7-4fba-87c3-9a32990de551), via openFDA
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the cimetidine label say about amiodarone?
Cimetidine's label (effective July 15, 2026) does not name amiodarone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Cimetidine | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.236 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once