What the FDA labels say about taking them together
Amiodarone and bosentan
Bosentan's FDA label of November 17, 2025 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name bosentan. The bosentan label: “Concomitant administration of both a CYP2C9 inhibitor and a strong CYP3A inhibitor or a moderate CYP3A inhibitor with TRACLEER will likely lead to large increases in plasma concentrations of bosentan.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.).
What does the amiodarone label say about bosentan?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name bosentan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the bosentan label say about amiodarone?
Bosentan label, drug interactionsConcomitant administration of both a CYP2C9 inhibitor (such as fluconazole or amiodarone) and a strong CYP3A inhibitor (e.g., ketoconazole, itraconazole) or a moderate CYP3A inhibitor (e.g., amprenavir, erythromycin, fluconazole, diltiazem) with TRACLEER will likely lead to large increases in plasma concentrations of bosentan.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Bosentan | |
|---|---|---|
| Labeled for | n/a | Pulmonary arterial hypertension |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once