What the FDA labels say about taking them together
Amiodarone and betaxolol
Betaxolol's FDA label of December 20, 2023 names amiodarone in its drug interactions section; amiodarone's label does not name betaxolol itself but warns about its class (Beta blockers). The betaxolol label: “Antiarrhythmics and Digitalis The concomitant use of a beta-adrenergic receptor inhibitor with calcium antagonists, antiarrhythmics (including amiodarone) or digitalis may have additive effects resulting in hypotension …”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the betaxolol FDA label on DailyMed (effective December 20, 2023, Epic Pharma LLC).
What does the amiodarone label say about betaxolol?
Amiodarone's label does not name betaxolol itself; it warns about its class (Beta blockers):
Amiodarone label, drug interactionsNegative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the betaxolol label say about amiodarone?
Betaxolol label, drug interactionsAmiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta blockers.
Betoptic S label (Novartis Pharmaceuticals Corporation, January 22, 2025), drug interactionsAntiarrhythmics and Digitalis The concomitant use of a beta-adrenergic receptor inhibitor with calcium antagonists, antiarrhythmics (including amiodarone) or digitalis may have additive effects resulting in hypotension and/or marked bradycardia.
Source: FDA drug label (Betoptic S, NDA019845), Novartis Pharmaceuticals Corporation, effective January 22, 2025 (SPL set 905ba189-456c-4aa4-8231-39a971374ad8), via openFDA
Source: FDA drug label (Betaxolol), Epic Pharma LLC, effective December 20, 2023 (SPL set bf716efe-0a9f-43b1-9d8a-c69330b82e18), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Betaxolol | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Glaucoma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once