What the FDA labels say about taking them together
Amiloride and spironolactone
Amiloride's FDA label of May 5, 2023 names spironolactone in its contraindications section; the spironolactone labels PlainMeds reads (2) do not name amiloride.
Check it at the source: the amiloride FDA label on DailyMed (effective May 5, 2023, Padagis US LLC); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the amiloride label say about spironolactone?
Amiloride label, contraindicationsAntikaliuretic Therapy or Potassium Supplementation Amiloride HCl should not be given to patients receiving other potassium-conserving agents, such as spironolactone or triamterene.
Source: FDA drug label (amiloride hydrochloride), Padagis US LLC, effective May 5, 2023 (SPL set 2b70cf0c-45be-428f-b396-5001ed4e30fc), via openFDA; the full label on DailyMed
What does the spironolactone label say about amiloride?
Spironolactone's label (effective November 28, 2025) and its 1 other brand-application label do not name amiloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiloride | Spironolactone | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.190 per tablet 5 mg tablet | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once