What the FDA labels say about taking them together
Amiloride and captopril
Captopril's FDA label of February 6, 2026 names amiloride in its drug interactions section; amiloride's label does not name captopril itself but warns about its class (ACE inhibitors). The captopril label: “Potassium-sparing diuretics such as spironolactone, triamterene, or amiloride, or potassium supplements should be given only for documented hypokalemia, and then with caution, since they may lead to a significant …”
Check it at the source: the amiloride FDA label on DailyMed (effective May 5, 2023, Padagis US LLC); the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.).
What does the amiloride label say about captopril?
Amiloride's label does not name captopril itself; it warns about its class (ACE inhibitors):
Amiloride label, warningsThe risk of hyperkalemia may be increased when potassium-conserving agents, including amiloride HCl, are administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus. (See PRECAUTIONS, Drug Interactions .) Warning signs or symptoms of hyperkalemia include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, shock, and ECG abnormalities.
Amiloride label, drug interactionsDrug Interactions When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased.
Source: FDA drug label (amiloride hydrochloride), Padagis US LLC, effective May 5, 2023 (SPL set 2b70cf0c-45be-428f-b396-5001ed4e30fc), via openFDA; the full label on DailyMed
What does the captopril label say about amiloride?
Captopril label, drug interactionsPotassium-sparing diuretics such as spironolactone, triamterene, or amiloride, or potassium supplements should be given only for documented hypokalemia, and then with caution, since they may lead to a significant increase of serum potassium.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiloride | Captopril | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | High blood pressure, Heart failure, Chronic kidney disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.190 per tablet 5 mg tablet | $0.228 per tablet 12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once