What the FDA labels say about taking them together
Amikacin and indomethacin
Indomethacin's FDA label (Indomethacin) of January 19, 2026 names amikacin in its drug interactions section; the amikacin labels PlainMeds reads (2) do not name indomethacin. The indomethacin label: “In one study of premature infants treated with Indomethacin for Injection and also receiving either gentamicin or amikacin, both peak and trough levels of these aminoglycosides were significantly elevated.”
Check it at the source: the amikacin FDA label on DailyMed (effective December 10, 2025, Qilu Pharmaceutical Co., Ltd.); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the amikacin label say about indomethacin?
Amikacin's label (effective December 10, 2025) and its 1 other brand-application label do not name indomethacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amikacin Sulfate), Qilu Pharmaceutical Co., Ltd., effective December 10, 2025 (SPL set 20fa61ef-11e2-4d01-82ea-b5412cefaead), via openFDA; the full label on DailyMed
What does the indomethacin label say about amikacin?
Indomethacin label (Fresenius Kabi USA, LLC, January 19, 2026), drug interactionsIn one study of premature infants treated with Indomethacin for Injection and also receiving either gentamicin or amikacin, both peak and trough levels of these aminoglycosides were significantly elevated.
Source: FDA drug label (Indomethacin, NDA022536), Fresenius Kabi USA, LLC, effective January 19, 2026 (SPL set ec482425-358c-4500-8f5d-79c1379c1fa8), via openFDA
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amikacin | Indomethacin | |
|---|---|---|
| Labeled for | Bacterial infections | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.33 per mL 500 mg/2 mL vial | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once