What the FDA labels say about taking them together
Amantadine and bupropion
Bupropion's FDA label of June 21, 2024 names amantadine in its drug interactions section; the amantadine labels PlainMeds reads (2) do not name bupropion. The bupropion label: “Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with APLENZIN.”
Check it at the source: the amantadine FDA label on DailyMed (effective January 30, 2026, Strides Pharma Inc.); the bupropion FDA label on DailyMed (effective June 21, 2024).
What does the amantadine label say about bupropion?
Amantadine's label (effective January 30, 2026) and its 1 other brand-application label do not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amantadine Hydrochloride), Strides Pharma Inc., effective January 30, 2026 (SPL set e4d8f36f-d668-4728-8dca-b1c22bd9aedb), via openFDA; the full label on DailyMed
What does the bupropion label say about amantadine?
Bupropion label, drug interactionsDopaminergic drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with bupropion hydrochloride extended-release tablets (SR).
Source: FDA drug label (Aplenzin, NDA022108), Bausch Health US, LLC, effective March 4, 2026 (SPL set 6494d2d9-0ce4-4126-b1c7-49684395942b), via openFDA
Source: FDA drug label (Wellbutrin Xl, NDA021515), Bausch Health US LLC, effective February 10, 2026 (SPL set a435da9d-f6e8-4ddc-897d-8cd2bf777b21), via openFDA
Source: FDA drug label (Bupropion Hcl Er (Xl), NDA022497), Lifestar Pharma LLC, effective February 4, 2026 (SPL set df959e1b-3f6d-42cf-8521-fe03b5a4ceb8), via openFDA
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amantadine | Bupropion | |
|---|---|---|
| Labeled for | Influenza, Parkinson's disease | Depression, Quitting smoking |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.143 per capsule 100 mg capsule | $0.0785 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once