What the FDA labels say about taking them together
Almotriptan and sertraline
Almotriptan's FDA label of December 31, 2025 names sertraline in its warnings and precautions section; the sertraline labels PlainMeds reads (3) do not name almotriptan. The almotriptan label: “If concomitant treatment with almotriptan tablets and an SSRI or SNRI is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.”
Check it at the source: the almotriptan FDA label on DailyMed (effective December 31, 2025, Ajanta Pharma USA Inc.); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the almotriptan label say about sertraline?
Almotriptan label, warnings and precautionsIf concomitant treatment with almotriptan tablets and an SSRI (e.g., fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram) or SNRI (e.g., venlafaxine, duloxetine) is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.
Source: FDA drug label (almotriptan), Ajanta Pharma USA Inc., effective December 31, 2025 (SPL set 6fa380c4-c885-4743-85bf-88819ae68645), via openFDA; the full label on DailyMed
What does the sertraline label say about almotriptan?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name almotriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Almotriptan | Sertraline | |
|---|---|---|
| Labeled for | Migraine, Pain | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $16.86 per tablet 12.5 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once