What the FDA labels say about taking them together
Allopurinol and febuxostat
Febuxostat's FDA label of December 24, 2025 names allopurinol in its boxed warning section; the allopurinol labels PlainMeds reads (4) do not name febuxostat. The febuxostat label: “ULORIC should only be used in patients who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable.”
Check it at the source: the allopurinol FDA label on DailyMed (effective May 21, 2026, Rising Pharma Holdings, Inc.); the febuxostat FDA label on DailyMed (effective December 24, 2025, Takeda Pharmaceuticals America, Inc.).
What does the allopurinol label say about febuxostat?
Allopurinol's label (effective May 21, 2026) and its 3 other brand-application labels do not name febuxostat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Allopurinol), Rising Pharma Holdings, Inc., effective May 21, 2026 (SPL set 30ad5ba2-1cef-4933-b104-0597f6a2aaa2), via openFDA; the full label on DailyMed
What does the febuxostat label say about allopurinol?
Febuxostat label, boxed warningULORIC should only be used in patients who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable [see Indications and Usage (1) ].
Febuxostat label, warnings and precautionsBecause of the increased risk of CV death, ULORIC should only be used in patients who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable [see Indications and Usage(1) ].
Source: FDA drug label (ULORIC), Takeda Pharmaceuticals America, Inc., effective December 24, 2025 (SPL set 54de10ef-fe5f-4930-b91d-6bbb04c664bd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Allopurinol | Febuxostat | |
|---|---|---|
| Labeled for | Gout | Gout |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0315 per tablet 100 mg tablet | $0.191 per tablet 40 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once