What the FDA labels say about taking them together
Alfuzosin and cobicistat
Cobicistat's FDA label of February 10, 2026 names alfuzosin in its contraindications section; the alfuzosin label PlainMeds reads does not name cobicistat. The cobicistat label: “Coadministration with alfuzosin is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.”
Check it at the source: the alfuzosin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the alfuzosin label say about cobicistat?
Alfuzosin's label (effective December 5, 2024) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Uroxatral), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set 9fc7f119-f36b-44cf-945d-940160f3afe3), via openFDA; the full label on DailyMed
What does the cobicistat label say about alfuzosin?
Cobicistat label, contraindicationsAlpha 1-adrenoreceptor antagonist: alfuzosin Antianginal: ranolazine Antiarrhythmic: dronedarone Anticonvulsants: carbamazepine, phenobarbital, phenytoin Anti-gout: colchicine Antimycobacterial: rifampin Antineoplastics: irinotecan These contraindications apply only to TYBOST coadministered with atazanavir Antipsychotics: lurasidone, pimozide Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine Herbal Products:
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Alpha 1- adrenoreceptor antagonist: alfuzosin; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ alfuzosin; Clinical Comment: Coadministration with alfuzosin is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alfuzosin | Cobicistat | |
|---|---|---|
| Labeled for | Enlarged prostate (BPH) | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.105 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once