What the FDA labels say about taking them together
Adenosine and caffeine
Adenosine's FDA label of April 14, 2025 names caffeine in its drug interactions section; the caffeine labels PlainMeds reads (2) do not name adenosine. The adenosine label: “Use of methylxanthines is not recommended in patients who experience a seizure in association with adenosine Hypersensitivity. Dyspnea, throat tightness, flushing, erythema, rash, and chest discomfort have occurred.”
Check it at the source: the adenosine FDA label on DailyMed (effective April 14, 2025, Meitheal Pharmaceuticals Inc.); the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals).
What does the adenosine label say about caffeine?
Adenosine label, drug interactionsDrugs on Adenosine The vasoactive effects of adenosine are inhibited by adenosine receptor antagonists, (such as methylxanthines (e.g., caffeine, aminophylline, and theophylline).
Adenosine label, warnings and precautionsUse of methylxanthines (e.g., caffeine, aminophylline and theophylline) is not recommended in patients who experience a seizure in association with adenosine ( 5.6 ) Hypersensitivity. Dyspnea, throat tightness, flushing, erythema, rash, and chest discomfort have occurred.
Source: FDA drug label (Adenosine), Meitheal Pharmaceuticals Inc., effective April 14, 2025 (SPL set b6851256-6cef-4f23-8129-19bb64380cd5), via openFDA; the full label on DailyMed
What does the caffeine label say about adenosine?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name adenosine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Adenosine | Caffeine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.083 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once