What the FDA labels say about taking them together
Adefovir dipivoxil and tenofovir alafenamide
Adefovir dipivoxil's FDA label of July 22, 2025 names tenofovir alafenamide in its warnings and precautions section; the tenofovir alafenamide label PlainMeds reads does not name adefovir dipivoxil.
Check it at the source: the adefovir dipivoxil FDA label on DailyMed (effective July 22, 2025, Apotex Corp.); the tenofovir alafenamide FDA label on DailyMed (effective July 14, 2025, Gilead Sciences, Inc.).
What does the adefovir dipivoxil label say about tenofovir alafenamide?
Adefovir dipivoxil label, warnings and precautionsAdefovir dipivoxil should not be used concurrently with products containing tenofovir disoproxil fumarate or tenofovir alafenamide.
Source: FDA drug label (Adefovir dipivoxil), Apotex Corp., effective July 22, 2025 (SPL set 08e07fae-3191-b6a3-c894-d3a8cc53923f), via openFDA; the full label on DailyMed
What does the tenofovir alafenamide label say about adefovir dipivoxil?
Tenofovir alafenamide's label (effective July 14, 2025) does not name adefovir dipivoxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VEMLIDY), Gilead Sciences, Inc., effective July 14, 2025 (SPL set 72e6b33c-0351-4070-9172-eeaa186c01d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Adefovir dipivoxil | Tenofovir alafenamide | |
|---|---|---|
| Labeled for | Hepatitis B | Hepatitis B |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $21.73 per tablet 10 mg tablet | $51.98 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once