What the FDA labels say about taking them together
Acitretin and phenytoin
Acitretin's FDA label of August 5, 2026 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name acitretin. The acitretin label: “If acitretin is given concurrently with phenytoin, the protein binding of phenytoin may be reduced.”
Check it at the source: the acitretin FDA label on DailyMed (effective August 5, 2026, Sigmapharm Laboratories, LLC); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the acitretin label say about phenytoin?
Acitretin label, drug interactionsIf acitretin is given concurrently with phenytoin, the protein binding of phenytoin may be reduced.
Source: FDA drug label (ACITRETIN), Sigmapharm Laboratories, LLC, effective August 5, 2026 (SPL set a6546625-acb8-460e-b34e-f795bfb3680a), via openFDA; the full label on DailyMed
What does the phenytoin label say about acitretin?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name acitretin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acitretin | Phenytoin | |
|---|---|---|
| Labeled for | Psoriasis | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2.59 per capsule 10 mg capsule | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once