What the FDA labels say about taking them together
Acitretin and doxycycline
Doxycycline's FDA label (Oracea) of April 16, 2025 names acitretin in its drug interactions section; the acitretin label PlainMeds reads does not name doxycycline. The doxycycline label: “Since both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should …”
Check it at the source: the acitretin FDA label on DailyMed (effective August 5, 2026, Sigmapharm Laboratories, LLC); the doxycycline FDA label on DailyMed (effective July 25, 2025, Chartwell RX, LLC.).
What does the acitretin label say about doxycycline?
Acitretin's label (effective August 5, 2026) does not name doxycycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ACITRETIN), Sigmapharm Laboratories, LLC, effective August 5, 2026 (SPL set a6546625-acb8-460e-b34e-f795bfb3680a), via openFDA; the full label on DailyMed
What does the doxycycline label say about acitretin?
Oracea label (Galderma Laboratories, L.P., April 16, 2025), drug interactionsSince both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should be avoided.
Source: FDA drug label (Oracea, NDA050805), Galderma Laboratories, L.P., effective April 16, 2025 (SPL set aa15c93a-ff4c-447a-8a21-96da506d8997), via openFDA
Source: FDA drug label (Doxycycline Monohydrate), Chartwell RX, LLC., effective July 25, 2025 (SPL set 02aa8731-d40f-43d8-8b63-a79a0503f8db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acitretin | Doxycycline | |
|---|---|---|
| Labeled for | Psoriasis | Urinary tract infections, Bacterial infections, Acne |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2.59 per capsule 10 mg capsule | $0.118 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once