What the FDA labels say about taking them together
Acetaminophen/benzhydrocodone and linezolid
Acetaminophen/benzhydrocodone's FDA label of January 7, 2025 names linezolid in its drug interactions section; the linezolid labels PlainMeds reads (3) do not name acetaminophen/benzhydrocodone. The acetaminophen/benzhydrocodone label: “The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.”
Check it at the source: the acetaminophen/benzhydrocodone FDA label on DailyMed (effective January 7, 2025, Zevra Therapeutics, Inc.); the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.).
What does the acetaminophen/benzhydrocodone label say about linezolid?
Acetaminophen/benzhydrocodone label, drug interactionsSerotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome. … monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Source: FDA drug label (APADAZ), Zevra Therapeutics, Inc., effective January 7, 2025 (SPL set 0590d4e5-7107-4015-a6a8-deac14265aa2), via openFDA; the full label on DailyMed
What does the linezolid label say about acetaminophen/benzhydrocodone?
Linezolid's label (effective June 19, 2026) and its 2 other brand-application labels do not name acetaminophen/benzhydrocodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/benzhydrocodone | Linezolid | |
|---|---|---|
| Labeled for | Pain | Bacterial infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $1.44 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once