What the FDA labels say about taking them together
Abiraterone and methylprednisolone
Abiraterone's FDA label (Yonsa) of June 8, 2026 names methylprednisolone in its warnings and precautions section; the methylprednisolone labels PlainMeds reads (3) do not name abiraterone. The abiraterone label: “Use of YONSA plus methylprednisolone in combination with radium Ra 223 dichloride is not recommended.”
Check it at the source: the abiraterone FDA label on DailyMed (effective March 28, 2025, Janssen Biotech, Inc.); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the abiraterone label say about methylprednisolone?
Yonsa label (Sun Pharmaceutical Industries, Inc., June 8, 2026), warnings and precautionsUse of YONSA plus methylprednisolone in combination with radium Ra 223 dichloride is not recommended.
Source: FDA drug label (Yonsa, NDA210308), Sun Pharmaceutical Industries, Inc., effective June 8, 2026 (SPL set b8967e10-f768-47ce-ac9e-2324c8390132), via openFDA
Source: FDA drug label (Zytiga), Janssen Biotech, Inc., effective March 28, 2025 (SPL set 4e338e89-3cf2-48eb-b6e2-a06c608c6513), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about abiraterone?
Methylprednisolone's label (effective June 22, 2026) and its 2 other brand-application labels do not name abiraterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abiraterone | Methylprednisolone | |
|---|---|---|
| Labeled for | Prostate cancer | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.774 per tablet 250 mg tablet | $0.121 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once