Prescription medicine
Secnidazole Brand names: Solosec
Secnidazole (Solosec) is a prescription medicine with an FDA approval on record since 2017. No generic is listed; pharmacies paid $281.96 per packet (Solosec 2 g granule packet) in the October 7, 2026 NADAC survey.
- No generic listed
Check it at the source: the secnidazole FDA label on DailyMed (effective February 19, 2025, Evofem Inc.); the NDA 209363 record on Drugs@FDA; every secnidazole label on DailyMed.
Highlights of the record
FDA label of February 19, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageSOLOSEC ® is a nitroimidazole antimicrobial indicated for: Treatment of bacterial vaginosis in female patients 12 years of age and older.
Forms and strengths
- 2 g/4.8g
Granule.
On the market
- Earliest approval on file
- September 15, 2017 Solosec, Evofem Inc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
- Last listed patent
- December 11, 2041 Solosec granule; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $281.96 per packet Solosec 2 g granule packet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 281 through July 30, 2026
What is secnidazole used for?
From the label: indications and usageSOLOSEC ® is a nitroimidazole antimicrobial indicated for: Treatment of bacterial vaginosis in female patients 12 years of age and older. ( 1.1 ) Treatment of trichomoniasis in patients 12 years of age and older. ( 1.2 ) To reduce the development of drug-resistant bacteria and maintain the effectiveness of SOLOSEC and other antibacterial drugs, SOLOSEC should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. […]
FDA pharmacologic class: Nitroimidazole Antimicrobial.
Source: FDA drug label (Solosec), Evofem Inc., effective February 19, 2025 (SPL set 056485b6-8bba-4a21-ae00-cdb4e7ae4bfa), via openFDA; the full label on DailyMed
What does the patient leaflet for secnidazole say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What should I avoid while taking SOLOSEC?Avoid drinking alcohol during treatment with SOLOSEC and for 2 days (48 hours) after you take SOLOSEC because the following side effects may happen: nausea vomiting diarrhea stomach (abdominal) pain dizziness headache
Source: FDA drug label (Solosec), Evofem Inc., effective February 19, 2025 (SPL set 056485b6-8bba-4a21-ae00-cdb4e7ae4bfa), via openFDA; the full label on DailyMed
Is there a generic for secnidazole (Solosec)?
No generic secnidazole is approved (Drugs@FDA, October 8, 2026).
The Orange Book lists 11 patents for Solosec granule, the last expiring on December 11, 2041. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 2017 earliest approval on file
- 2041 last listed patent
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for secnidazole (Solosec)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $281.96 per packet (Solosec 2 g granule packet), up 4% from $271.99 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Solosec 2 g granule packet (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Solosec 2 g granule packet | Brand | $281.96 per packet | n/a | +4% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the secnidazole label say about other medicines?
The secnidazole label names 2 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Metronidazole | contraindications | In patients with Cockayne syndrome: Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes have been reported after initiation of metronidazole, another nitroimidazole drug, structurally related to secnidazole, in patients with Cockayne syndrome [see Adverse Reactions (6.2) ]. |
| Norethindrone | drug interactions | DRUG INTERACTIONS 7.1 Oral Contraceptives There was no clinically significant drug interaction between secnidazole and the combination oral contraceptive, ethinyl estradiol plus norethindrone [see Clinical Pharmacology (12.3) ]. |
Source: FDA drug label (Solosec), Evofem Inc., effective February 19, 2025 (SPL set 056485b6-8bba-4a21-ae00-cdb4e7ae4bfa), via openFDA; the full label on DailyMed
What do FAERS reports show for secnidazole?
The FDA Adverse Event Reporting System holds 281 reports that list secnidazole among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 3 are coded as a death and 21 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other nitroimidazole antimicrobials
- the pharmacologic class, with prices and generics
- Secnidazole side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other