Prescription medication · Rho Kinase Inhibitor / PGA Combination

netarsudil/latanoprost

Also sold as Rocklatan. Rocklatan is used to lower high pressure in your eyes.

Data updated 2026-05-15

1,191
FDA reports
1
InteractionFew interactions
$131.84
Brand price (NADAC)

What the data shows

netarsudil/latanoprost (Rocklatan) is a prescription Rho Kinase Inhibitor / PGA Combination, with 1,191 FDA adverse-event reports on file, with 1 documented drug interaction.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

netarsudil/latanoprost (Rocklatan) is a prescription Rho Kinase Inhibitor / PGA Combination. Rocklatan is used to lower high pressure in your eyes.

Rocklatan is an eye drop medicine that lowers pressure inside the eye. It is used for people with open-angle glaucoma or ocular hypertension.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$131.84/unit

Generic Available

No

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Rocklatan is used to lower high pressure in your eyes.

Common side effects

Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%)

Key warnings

Rocklatan can cause changes in eye color, eyelid, and eyelashes.

The sections below are summarized in plain English from netarsudil/latanoprost's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Rocklatan contains two medicines that work together. One medicine helps to relax eye tissues to allow fluid to drain better. The other medicine helps to reduce the amount of fluid your eye makes. This combination lowers the pressure in your eye.

Side Effects (from patient reports)

Based on 1,191 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for netarsudil/latanoprost, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

Rocklatan can cause changes in eye color, eyelid, and eyelashes. The color change in the iris (colored part of the eye) may be permanent. Eyelash changes, like increased length and thickness, are usually reversible when you stop using Rocklatan. This medicine may also cause swelling in the cornea, especially if you have existing cornea problems or have had eye surgery. Tell your doctor if you have eye pain or vision changes.

Known Drug Interactions

moderate latanoprost

The combined use of two or more prostaglandins or prostaglandin analogs including latanoprost ophthalmic solution 0.005% is not recommended.

Mechanism: Both drugs are in the same family and work the same way. Using more than one at a time can actually make them less effective at lowering eye pressure.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I use Rocklatan more than once a day to lower my eye pressure faster?
No, do not use Rocklatan more than once a day. Using it more often may make it less effective.
What should I do if I wear contact lenses?
Remove your contact lenses before using Rocklatan. You can put them back in 15 minutes after using the drops.
How long does it take for Rocklatan to start working?
Rocklatan starts working soon after you use it, but it may take a few weeks to see the full effect on your eye pressure.
Can I use Rocklatan with other eye drops?
Yes, you can use Rocklatan with other eye drops, but wait at least 5 minutes between using each medicine.
What if I accidentally get Rocklatan in my mouth?
Rinse your mouth with water. If you feel unwell, contact your doctor.
Can Rocklatan cause my eyelashes to grow longer?
Yes, Rocklatan can cause your eyelashes to grow longer, thicker, and darker. These changes are usually reversible when you stop using the medicine.
Will Rocklatan change my eye color?
Yes, Rocklatan can cause the colored part of your eye (iris) to become more brown. This change may be permanent.
What should I do if I experience eye pain or vision changes while using Rocklatan?
Tell your doctor right away if you have eye pain or vision changes.
Can I drive or operate machinery after using Rocklatan?
Rocklatan may cause blurred vision temporarily. Do not drive or operate machinery until your vision is clear.
How long can I use Rocklatan after opening the bottle?
You can use Rocklatan for up to 6 weeks after opening the bottle if stored at room temperature, or until the expiration date if refrigerated.
What are the common side effects of netarsudil/latanoprost?
The registry lists Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%), Bleeding in the eye (11%) among the most-reported FAERS reaction terms for netarsudil/latanoprost. The compiled record contains 1,191 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does netarsudil/latanoprost interact with other medications?
The registry has 1 documented interaction rows for netarsudil/latanoprost. Notable source-record pairings include latanoprost. These rows are not a complete medication review.
What drug class is netarsudil/latanoprost?
netarsudil/latanoprost belongs to the Rho Kinase Inhibitor / PGA Combination drug class. It requires a prescription (Rx). Rocklatan is used to lower high pressure in your eyes.
What pregnancy or breastfeeding source fields are listed for netarsudil/latanoprost?
The FDA label for netarsudil/latanoprost contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Rho Kinase Inhibitor / PGA Combination

Other drugs grouped near netarsudil/latanoprost - same-class peers and common alternatives.

aflibercept

Eylea

AHZANTIVE is a medicine used to treat certain eye problems.

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artificial tears

Refresh, Systane

Artificial tears are eye drops that lubricate your eyes.

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bevacizumab (ophthalmic)

Avastin

Avastin is a medicine that blocks a protein called vascular endothelial growth factor (VEGF).

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bimatoprost

Lumigan

Bimatoprost eye drops help lower pressure in the eye.

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brimonidine ophthalmic

Alphagan P

Alphagan P eye drops help lower pressure in the eye.

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What the FDA Data Shows for netarsudil/latanoprost

The FDA label for netarsudil/latanoprost (sold under brand names such as Rocklatan) classifies it as a prescription-only medication in the Rho Kinase Inhibitor / PGA Combination class. Rocklatan is used to lower high pressure in your eyes. Official labeling lists 4 commonly reported side effects, including Redness of the eye (59%), Pain where the drop is applied (20%), Changes in the cornea (15%).

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,191 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: January 20, 2026

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page