Prescription medicine
Magnesium chloride, potassium chloride and 3 other ingredients Brand names: Normosol-R, Physiolyte, Isolyte, Plasma-Lyte, Multiple
Magnesium chloride, potassium chloride and 3 other ingredients (Normosol-R) is a prescription medicine with an FDA approval on record since 1975. FDA's NDC Directory lists it from 1 generic labeler.
- Generic listed
Check it at the source: the magnesium chloride, potassium chloride and 3 other ingredients FDA label on DailyMed (effective August 5, 2019, Baxter Healthcare Corporation); the NDA 17586 record on Drugs@FDA; every magnesium chloride, potassium chloride and 3 other ingredients label on DailyMed.
Highlights of the record
FDA label of August 5, 2019; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usagePLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is indicated as a source of water and electrolytes or as an alkalinizing agent.
Forms and strengths
- 0.53 g/100ml / 0.5 g/100ml / 0.37 g/100ml / 0.037 g/100ml / 0.03 g/100ml
- 526 mg/100ml / 502 mg/100ml / 368 mg/100ml / 37 mg/100ml / 30 mg/100ml
- 526 mg/100ml / 222 mg/100ml / 502 mg/100ml / 37 mg/100ml / 30 mg/100ml
Injection (solution); irrigant.
On the market
- Earliest approval on file
- August 13, 1975 Normosol-R In Plastic Container, Otsuka Icu Medcl; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 2 first June 8, 2022; 1 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 4 of which 1 under generic applications, 3 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 96 through July 30, 2026
What is magnesium chloride, potassium chloride and 3 other ingredients used for?
From the label: indications and usagePLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is indicated as a source of water and electrolytes or as an alkalinizing agent.
FDA pharmacologic class: Calculi Dissolution Agent, Osmotic Laxative and Potassium Salt.
Source: FDA drug label (Plasma-Lyte A), Baxter Healthcare Corporation, effective August 5, 2019 (SPL set 6ec9e61c-2c26-402f-8604-f446b2e34058), via openFDA; the full label on DailyMed
Is there a generic for magnesium chloride, potassium chloride and 3 other ingredients (Normosol-R)?
The FDA approved the first generic magnesium chloride, potassium chloride and 3 other ingredients on June 8, 2022. 2 generic applications are approved; 1 of them carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists magnesium chloride, potassium chloride and 3 other ingredients from 1 labeler under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1975 earliest approval on file
- 2022 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What does the magnesium chloride, potassium chloride and 3 other ingredients label say about other medicines?
The magnesium chloride, potassium chloride and 3 other ingredients label names 4 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Corticotropin | drug interactions | Avoid use of PLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) in patients receiving such products, such as corticosteroids or corticotropin. |
| Cyclosporine | drug interactions | … sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine. |
| Lithium | drug interactions | Lithium Renal clearance of lithium may be increased during administration of PLASMA-LYTE A Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP). |
| Tacrolimus | drug interactions | … potassium sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine. |
Check magnesium chloride, potassium chloride and 3 other ingredients against other medicines
Source: FDA drug label (Plasma-Lyte A), Baxter Healthcare Corporation, effective August 5, 2019 (SPL set 6ec9e61c-2c26-402f-8604-f446b2e34058), via openFDA; the full label on DailyMed
What do FAERS reports show for magnesium chloride, potassium chloride and 3 other ingredients?
The FDA Adverse Event Reporting System holds 96 reports that list magnesium chloride, potassium chloride and 3 other ingredients among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 20 are coded as a death and 43 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other calculi dissolution agents
- the pharmacologic class, with prices and generics
- Magnesium chloride, potassium chloride and 3 other ingredients side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other