Prescription medication · Tetracycline Antibiotic
eravacycline
Also sold as Xerava. Xerava treats complicated infections inside your belly (intra-abdominal).
Data updated 2026-05-15
- 205
- FDA reportsRarely reported
- Rx
- Availability
eravacycline (Xerava) is a prescription Tetracycline Antibiotic. Xerava treats complicated infections inside your belly (intra-abdominal).
Xerava is an antibiotic medicine. It is used to treat complicated infections in the stomach area.
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What it does
Xerava treats complicated infections inside your belly (intra-abdominal).
Common side effects
Reactions where the IV goes into your body, Feeling sick to your stomach (nausea), Throwing up
Key warnings
Xerava can cause serious allergic reactions.
The sections below are summarized in plain English from eravacycline's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Xerava is a tetracycline antibiotic. It stops bacteria from growing. This helps your body fight off the infection.
How to Take It
Xerava is given into your vein through an IV. You will get 1 mg of Xerava for each kg you weigh. This is given every 12 hours for 4 to 14 days. Each IV dose takes about 60 minutes.
This is a plain-language summary of eravacycline's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Xerava can harm an unborn baby. It can cause tooth discoloration and slow bone growth. Breastfeeding is not recommended while using Xerava.
This is a plain-language summary of eravacycline's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, talk to your doctor or nurse right away. They will tell you when to get your next dose.
This is a plain-language summary of eravacycline's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Keep Xerava in the fridge between 36°F and 46°F before mixing.
Side Effects (from patient reports)
Based on 205 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for eravacycline, by number of reports
- Blood Fibrinogen Decreased
Blood Fibrinogen Decreased
16 reports
- Nausea
Nausea
15 reports
- Thrombocytopenia
Thrombocytopenia
14 reports
- Multiple Organ Dysfunction Syndrome
Multiple Organ Dysfunction Syndrome
13 reports
- Lactic Acidosis
Lactic Acidosis
11 reports
- Hypertransaminasaemia
Hypertransaminasaemia
10 reports
- Diarrhoea
Diarrhoea
9 reports
- Pancreatitis
Pancreatitis
8 reports
- Acute Respiratory Distress Syndrome 6
Acute Respiratory Distress Syndrome
6 reports
- Condition Aggravated 6
Condition Aggravated
6 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for eravacycline each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where eravacycline sits
eravacycline has more FDA adverse-event reports than 2% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is eravacycline; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 205 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2019–2025.
Total Reports
205
Reports Mentioning Death
33
16.1% of reports — not proof of cause
Hospitalization Reports
57
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 3 | BLOOD FIBRINOGEN DECREASED | 16 |
| 4 | NAUSEA | 15 |
| 5 | THROMBOCYTOPENIA | 14 |
| 6 | MULTIPLE ORGAN DYSFUNCTION SYNDROME | 13 |
| 8 | LACTIC ACIDOSIS | 11 |
| 9 | HYPERTRANSAMINASAEMIA | 10 |
| 10 | DIARRHOEA | 9 |
| 11 | PANCREATITIS | 8 |
| 12 | ACUTE RESPIRATORY DISTRESS SYNDROME | 6 |
| 13 | CONDITION AGGRAVATED | 6 |
| 15 | ENTEROCOCCAL INFECTION | 6 |
| 16 | PROTHROMBIN TIME PROLONGED | 6 |
| 17 | SEPSIS | 6 |
| 18 | BLOOD BILIRUBIN INCREASED | 5 |
| 19 | DRUG INEFFECTIVE FOR UNAPPROVED INDICATION | 5 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Xerava can cause serious allergic reactions. If you are allergic to tetracycline antibiotics, you should not take Xerava. Using Xerava while teeth are developing can cause tooth discoloration. It can also slow bone growth in babies and children under 8.
Common Questions
What if I'm allergic to tetracyclines?
Can Xerava affect my teeth?
Can Xerava affect bone growth?
What should I do if I get diarrhea while taking Xerava?
Can I breastfeed while taking Xerava?
What if I am taking a blood thinner?
What if I am taking medicine that affects liver enzymes?
How long will I need to take Xerava?
How is Xerava given?
What does Xerava look like?
What are the common side effects of eravacycline?
What drug class is eravacycline?
Is eravacycline safe during pregnancy?
Related Medications in Tetracycline Antibiotic
Other drugs grouped near eravacycline - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with eravacycline →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
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amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with eravacycline →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with eravacycline →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
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What the FDA Data Shows for eravacycline
The FDA label for eravacycline (sold under brand names such as Xerava) classifies it as a prescription-only medication in the Tetracycline Antibiotic class. Xerava treats complicated infections inside your belly (intra-abdominal). Official labeling lists 3 commonly reported side effects, including Reactions where the IV goes into your body, Feeling sick to your stomach (nausea), Throwing up.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 205 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: September 22, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages