Prescription medicine
Echothiophate Brand names: Phospholine; first approved as Phospholine Iodide
Echothiophate (Phospholine Iodide) is a prescription medicine with an FDA approval on record since 1960. No generic is listed in FDA's NDC Directory.
- No generic listed
Check it at the source: the echothiophate FDA label on DailyMed (effective July 7, 2025, Fera Pharmaceuticals, LLC); the NDA 11963 record on Drugs@FDA; every echothiophate label on DailyMed.
Highlights of the record
FDA label of July 7, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageReduction of Elevated IOP Echothiophate iodide for ophthalmic solution is indicated for the reduction of elevated IOP.
Forms and strengths
Kit.
On the market
- Earliest approval on file
- June 27, 1960 Phospholine Iodide, Fera Pharms Llc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- None current 1 past records
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 146 through July 30, 2026
What is echothiophate used for?
From the label: indications and usageReduction of Elevated IOP Echothiophate iodide for ophthalmic solution is indicated for the reduction of elevated IOP. Accommodative Esotropia Concomitant esotropias with a significant accommodative component.
Source: FDA drug label (Phospholine Iodide), Fera Pharmaceuticals, LLC, effective July 7, 2025 (SPL set 8afc8951-db76-4f27-8752-7c0d6aa47244), via openFDA; the full label on DailyMed
Is there a generic for echothiophate (Phospholine Iodide)?
No generic echothiophate is approved (Drugs@FDA, October 8, 2026).
- 1960 earliest approval on file
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
Is echothiophate in shortage?
No echothiophate presentation is listed as limited or unavailable in the FDA Drug Shortage Database (read October 8, 2026); it keeps 1 current entry listed as available (updated September 1, 2026). ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Phospholine Iodide, Ophthalmic Solution, 0.125% (NDC 48102-053-05) | Fera Pharmaceuticals | Current | September 1, 2026 |
Every echothiophate presentation in the FDA shortage database
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
What does the echothiophate label say about other medicines?
The echothiophate label names 1 other medicine in its interaction, contraindication or warning sections. The labels of 2 other medicines name echothiophate. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Succinylcholine | drug interactions | Drug Interactions Echothiophate iodide for ophthalmic solution potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides. |
Source: FDA drug label (Phospholine Iodide), Fera Pharmaceuticals, LLC, effective July 7, 2025 (SPL set 8afc8951-db76-4f27-8752-7c0d6aa47244), via openFDA; the full label on DailyMed
What do FAERS reports show for echothiophate?
The FDA Adverse Event Reporting System holds 146 reports that list echothiophate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 1 are coded as a death and 5 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Echothiophate side effects
- the label's list beside FAERS reports
- Echothiophate shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other