Prescription medication · Selective Estrogen Receptor Modulator (Fertility)
clomiphene
Also sold as Clomid, Serophene. Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant.
Data updated 2026-05-15
- 731
- FDA reports
- $7.55
- Generic price (NADAC)
clomiphene (Clomid) is a prescription Selective Estrogen Receptor Modulator (Fertility). Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant.
Clomiphene citrate is a medicine that helps women ovulate. It is used to help women get pregnant.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$7.55/unit
Generic Available
Yes (6 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant.
Common side effects
Ovarian enlargement, Hot flashes, Abdominal or pelvic discomfort, bloating
Key warnings
Clomiphene citrate can cause ovarian hyperstimulation syndrome (OHSS).
The sections below are summarized in plain English from clomiphene's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
This medicine works by affecting estrogen levels in your body. It makes your body release hormones that cause your ovaries to release an egg. This can help you get pregnant.
How to Take It
Take clomiphene citrate exactly as your doctor tells you. Usually, you will take one 50 mg tablet daily for 5 days. Start on or around the 5th day of your menstrual cycle. Have sex around the time you expect to ovulate. Your doctor may adjust your dose based on how you respond.
This is a plain-language summary of clomiphene's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
You should not take clomiphene citrate if you are pregnant. It can cause problems with the baby's development. Talk to your doctor if you become pregnant while taking this medicine.
This is a plain-language summary of clomiphene's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of clomiphene's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store tablets at room temperature (59° to 86°F). Keep away from heat, light, and moisture.
Side Effects (from patient reports)
Based on 731 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for clomiphene, by number of reports
- Miscarriage
Miscarriage
109 reports
- Baby exposed to drug during pregnancy
Baby exposed to drug during pregnancy
107 reports
- Feeling sick to your stomach
Feeling sick to your stomach
87 reports
- Head pain
Head pain
80 reports
- Exposure during pregnancy
Exposure during pregnancy
73 reports
- Throwing up
Throwing up
64 reports
- Feeling tired
Feeling tired
57 reports
- Mother exposed to drug during pregnancy
Mother exposed to drug during pregnancy
53 reports
- Loose stools
Loose stools
52 reports
- Fetus exposed to drug during pregnancy
Fetus exposed to drug during pregnancy
49 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Serious Warnings
Clomiphene citrate can cause ovarian hyperstimulation syndrome (OHSS). This is a serious condition where your ovaries get too large and fluid builds up in your body. Call your doctor right away if you have severe pelvic pain, nausea, vomiting, weight gain, or trouble breathing.
Common Questions
How long can I take clomiphene citrate?
What if I don't ovulate after the first course?
Can clomiphene citrate cause twins?
What tests will I need while taking this medicine?
When should I have sex while taking clomiphene citrate?
What if I don't get pregnant after taking clomiphene citrate?
Can clomiphene citrate cause mood changes?
What should I do if I have blurry vision?
Can I take clomiphene citrate if I have liver problems?
Can I take clomiphene citrate if I have ovarian cysts?
What are the common side effects of clomiphene?
What drug class is clomiphene?
Is clomiphene safe during pregnancy?
Related Medications in Selective Estrogen Receptor Modulator (Fertility)
Other drugs grouped near clomiphene - same-class peers and common alternatives.
abiraterone
Zytiga
Abiraterone (Zytiga) is a medicine used with prednisone to treat prostate cancer that has spread.
Compare with clomiphene →
anastrozole
Arimidex
Anastrozole is a medicine used to treat breast cancer in women after menopause.
Compare with clomiphene →
bazedoxifene/conjugated estrogens
Duavee
Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body.
Compare with clomiphene →
cabergoline
Dostinex
Cabergoline is a medicine that helps lower the amount of prolactin in your body.
Compare with clomiphene →
conjugated estrogens
Premarin
Premarin Intravenous is an injectable medicine that contains estrogen hormones.
Compare with clomiphene →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Save on clomiphene
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for clomiphene
The FDA label for clomiphene (sold under brand names such as Clomid, Serophene) classifies it as a prescription-only medication in the Selective Estrogen Receptor Modulator (Fertility) class. Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant. Official labeling lists 9 commonly reported side effects, including Ovarian enlargement, Hot flashes, Abdominal or pelvic discomfort, bloating.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 731 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS shows a generic unit cost of $7.55.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: September 18, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages