Prescription medicine
Clindamycin and tretinoin Brand names: Ziana
Clindamycin and tretinoin (Ziana) is a prescription medicine with an FDA approval on record since 2006. FDA's NDC Directory lists it from 3 generic labelers, and pharmacies paid $3.91 per gram (Clinda-tretinoin 1.2%-0.025%) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the clindamycin and tretinoin FDA label on DailyMed (effective May 15, 2026, Bausch Health US, LLC); the NDA 50802 record on Drugs@FDA; every clindamycin and tretinoin label on DailyMed.
Highlights of the record
FDA label of May 15, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older.
Forms and strengths
- 10 mg/g / 0.25 mg/g
- 12 mg/g / 0.25 mg/g
Gel.
On the market
- Earliest approval on file
- November 7, 2006 Ziana, Bausch; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 3 first June 12, 2015; 3 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 5 of which 3 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $3.91 per gram Clinda-tretinoin 1.2%-0.025%
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 154 through July 30, 2026
What is clindamycin and tretinoin used for?
From the label: indications and usageZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older. ZIANA ® Gel is a lincosamide antibiotic and retinoid combination product indicated for the topical treatment of acne vulgaris in patients 12 years or older.
Conditions named in the indications of clindamycin and tretinoin's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Lincosamide Antibacterial and Retinoid.
Source: FDA drug label (ZIANA), Bausch Health US, LLC, effective May 15, 2026 (SPL set 78c329f9-f0c9-486d-9e54-0123699fb9e1), via openFDA; the full label on DailyMed
Is there a generic for clindamycin and tretinoin (Ziana)?
The FDA approved the first generic clindamycin and tretinoin on June 12, 2015. 3 generic applications are approved; 3 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists clindamycin and tretinoin from 3 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 2006 earliest approval on file
- 2015 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for clindamycin and tretinoin (Ziana)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $3.91 per gram (Clinda-tretinoin 1.2%-0.025%), down 27% from $5.35 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Clinda-tretinoin 1.2%-0.025% (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Clinda-tretinoin 1.2%-0.025% | Generic | $3.91 per gram | n/a | -27% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the clindamycin and tretinoin label say about other medicines?
The clindamycin and tretinoin label names 1 other medicine in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Atropine | warnings and precautions | Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen severe colitis. |
Source: FDA drug label (ZIANA), Bausch Health US, LLC, effective May 15, 2026 (SPL set 78c329f9-f0c9-486d-9e54-0123699fb9e1), via openFDA; the full label on DailyMed
What do FAERS reports show for clindamycin and tretinoin?
The FDA Adverse Event Reporting System holds 154 reports that list clindamycin and tretinoin among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 3 are coded as a death and 25 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as clindamycin and tretinoin?
11 other medicines are given the same way (topical) and in the same FDA class as clindamycin and tretinoin or labeled mainly for the same use (acne), the same class first. Acne lists all 26 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (topical) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Adapalene | Acne | 34 labelers | $0.504 per gram 0.3% gel | No current entry |
| Adapalene and benzoyl peroxide | Acne | 11 labelers | $0.626 per gram 0.3-2.5% | No current entry |
| Tazarotene | Acne | 6 labelers | $6.11 per gram 0.1% gel | No current entry |
| Trifarotene | Acne | none listed | $16.36 per gram 0.005% cream | No current entry |
| Salicylic acid | Acne | none listed | $0.102 per patch Callus removers patch | No current entry |
| Benzoyl peroxide | Acne | none listed | $0.0469 per gram 10% wash | No current entry |
| Sulfur | Acne | none listed | n/a | No current entry |
| Dapsone | Acne | 16 labelers | $0.664 per gram 5% gel | A presentation being discontinued |
Every medicine labeled for the same conditions as clindamycin and tretinoin
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to clindamycin and tretinoin
- 11 medicines for the same use
- Other lincosamide antibacterials
- the pharmacologic class, with prices and generics
- Clindamycin and tretinoin side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other