Prescription medicine
Citric acid and lactic acid l- and potassium bitartrate Brand names: Phexxi, Phexx
Citric acid and lactic acid l- and potassium bitartrate (Phexxi) is a prescription medicine. No generic is listed; pharmacies paid $6.05 per gram (Phexxi 1.8-1-0.4% vaginal gel) in the October 7, 2026 NADAC survey.
- No generic listed
Check it at the source: the citric acid and lactic acid l- and potassium bitartrate FDA label on DailyMed (effective May 2, 2025); every citric acid and lactic acid l- and potassium bitartrate label on DailyMed.
Highlights of the record
FDA label of May 2, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usagePHEXX is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.
Forms and strengths
- 90 mg/5g / 50 mg/5g / 20 mg/5g
Gel.
On the market
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $6.05 per gram Phexxi 1.8-1-0.4% vaginal gel
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 175 through July 30, 2026
What is citric acid and lactic acid l- and potassium bitartrate used for?
From the label: indications and usagePHEXX is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception. PHEXX is a combination of lactic acid, citric acid, and potassium bitartrate indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception. ( 1 ) Limitations of Use: PHEXX is not effective for the prevention of pregnancy when administered after intercourse. Limitations of Use PHEXX is not effective for the prevention of pregnancy when administered after intercourse [ see Dosage and Administration (2.1) ].
Conditions named in the indications of citric acid and lactic acid l- and potassium bitartrate's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Anti-coagulant and Calculi Dissolution Agent.
Source: FDA drug label (Phexx), Evofem, Inc., effective May 2, 2025 (SPL set 14b01a15-9b47-4be3-bb2e-a2010eab429e), via openFDA; the full label on DailyMed
Is there a generic for citric acid and lactic acid l- and potassium bitartrate (Phexxi)?
No generic citric acid and lactic acid l- and potassium bitartrate is approved (Drugs@FDA, October 8, 2026).
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for citric acid and lactic acid l- and potassium bitartrate (Phexxi)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $6.05 per gram (Phexxi 1.8-1-0.4% vaginal gel), up 5% from $5.78 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Phexx 1.8-1-0.4% vaginal gel (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Phexx 1.8-1-0.4% vaginal gel | Brand | $6.05 per gram | n/a | n/a |
| Phexxi 1.8-1-0.4% vaginal gel | Brand | $6.05 per gram | n/a | +5% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for citric acid and lactic acid l- and potassium bitartrate?
The FDA Adverse Event Reporting System holds 175 reports that list citric acid and lactic acid l- and potassium bitartrate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 8 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as citric acid and lactic acid l- and potassium bitartrate?
2 other medicines are given the same way (vaginal) and in the same FDA class as citric acid and lactic acid l- and potassium bitartrate or labeled mainly for the same use (birth control), the same class first. Birth control lists all 24 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (vaginal) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Ethinyl estradiol and etonogestrel | Birth control | 5 labelers | $46.35 per ring Etonogestrel-ee vaginal ring | No current entry |
| Ethinyl estradiol and segesterone | Birth control | none listed | $2,315.29 per ring Annovera vaginal ring | No current entry |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Other anti-coagulants
- the pharmacologic class, with prices and generics
- Citric acid and lactic acid l- and potassium bitartrate side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other