Prescription medicine
Cefprozil First approved as Cefzil
Cefprozil (Cefzil) is a prescription medicine with an FDA approval on record since 1991. FDA's NDC Directory lists it from 7 generic labelers, and pharmacies paid $0.925 per cefprozil 500 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the cefprozil FDA label on DailyMed (effective May 5, 2024, Aurobindo Pharma Limited); the NDA 50665 record on Drugs@FDA; every cefprozil label on DailyMed.
Highlights of the record
FDA label of May 5, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageTo reduce the development of drug-resistant bacteria and maintain the effectiveness of cefprozil and other antibacterial drugs, cefprozil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
Forms and strengths
- 250 mg
- 500 mg
- 125 mg/5ml
- 250 mg/5ml
Film-coated tablet; powder for suspension; tablet.
On the market
- Earliest approval on file
- December 23, 1991 Cefzil, Corden Pharma; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 16 first November 14, 2005; 7 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 7 of which 7 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.925 per tablet Cefprozil 500 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 1 since 2021 0 Class I among all firms' recalls; latest March 26, 2021
- FAERS reports
- 780 through July 30, 2026
What is cefprozil used for?
From the label: indications and usageTo reduce the development of drug-resistant bacteria and maintain the effectiveness of cefprozil and other antibacterial drugs, cefprozil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. […]
Conditions named in the indications of cefprozil's FDA labels, with every medicine labeled for each:
From other cefprozil labelsBacterial infections: Cefprozil tablets are indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below:
FDA pharmacologic class: Cephalosporin Antibacterial.
Source: FDA drug label (Cefprozil), Aurobindo Pharma Limited, effective May 5, 2024 (SPL set b9111a81-07c4-4458-b994-a4ad504986d8), via openFDA; the full label on DailyMed
Is there a generic for cefprozil (Cefzil)?
The FDA approved the first generic cefprozil on November 14, 2005. 16 generic applications are approved; 7 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists cefprozil from 7 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1991 earliest approval on file
- 2005 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for cefprozil (Cefzil)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.925 per Cefprozil 500 mg tablet, down 11% from $1.04 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Cefprozil 250 mg/5 mL suspension (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Cefprozil 125 mg/5 mL suspension | Generic | $0.105 per mL | n/a | -22% |
| Cefprozil 250 mg tablet | Generic | $0.482 per tablet | $14.46 | -16% |
| Cefprozil 250 mg/5 mL suspension | Generic | $0.206 per mL | n/a | +16% |
| Cefprozil 500 mg tablet | Generic | $0.925 per tablet | $27.76 | -11% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has cefprozil been recalled?
The FDA's Enforcement Report lists 1 recall naming cefprozil since 2021: 0 Class I (the most serious), 1 Class II, 0 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| March 26, 2021 | Class II | Lupin Pharmaceuticals Inc. | Superpotent Drug |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the cefprozil label say about other medicines?
The cefprozil label names 2 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Epinephrine | warnings | SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. |
| Probenecid | drug interactions | Concomitant administration of probenecid doubled the AUC for cefprozil. |
Source: FDA drug label (Cefprozil), Aurobindo Pharma Limited, effective May 5, 2024 (SPL set b9111a81-07c4-4458-b994-a4ad504986d8), via openFDA; the full label on DailyMed
What do FAERS reports show for cefprozil?
The FDA Adverse Event Reporting System holds 780 reports that list cefprozil among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 48 are coded as a death and 306 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as cefprozil?
23 other medicines are given the same way (oral) and in the same FDA class as cefprozil or labeled mainly for the same use (bacterial infections), the same class first. Bacterial infections lists all 51 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Cephalexin | Bacterial infections | 36 labelers | $0.120 per capsule 500 mg capsule | No current entry |
| Cefdinir | Bacterial infections | 26 labelers | $0.458 per capsule 300 mg capsule | No current entry |
| Cefuroxime | Bacterial infections | 17 labelers | $0.280 per tablet 250 mg tablet | No current entry |
| Cefadroxil | Bacterial infections | 19 labelers | $0.269 per capsule 500 mg capsule | No current entry |
| Cefpodoxime | Bacterial infections | 11 labelers | $1.04 per tablet 100 mg tablet | No current entry |
| Cefixime | Bacterial infections | 6 labelers | $10.03 per capsule 400 mg capsule | No current entry |
| Amoxicillin | Bacterial infections | 38 labelers | $0.0788 per capsule 500 mg capsule | No current entry |
| Azithromycin | Bacterial infections | 47 labelers | $0.266 per tablet 250 mg tablet | A presentation being discontinued |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does cefprozil compare with medicines for the same use?
7 side-by-side pages set cefprozil beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to cefprozil
- 23 medicines for the same use
- Other cephalosporins
- the pharmacologic class, with prices and generics
- Cefprozil side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other