Two medicines, side by side
Cefprozil vs amoxicillin
Cefprozil and amoxicillin are both labeled for bacterial infections. Drugs@FDA records approvals of cefprozil since 1991 and of amoxicillin since 1974. Pharmacies paid $0.925 per cefprozil 500 mg tablet and $0.0788 per amoxicillin 500 mg capsule (NADAC, October 7, 2026). In FDA's classes, cefprozil is a cephalosporin antibacterial and amoxicillin a penicillin-class antibacterial.
Check it at the source: the cefprozil FDA label on DailyMed (effective May 5, 2024); the amoxicillin FDA label on DailyMed (effective February 22, 2024).
Highlights of the cefprozil record
Cefprozil (Cefzil) · label of May 5, 2024
Used for
From the label: indicationsTo reduce the development of drug-resistant bacteria and maintain the effectiveness of cefprozil and other antibacterial drugs, cefprozil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. […]
On the market
- Earliest approval on file
- December 23, 1991
- Generic labelers
- 7 labelers
- Pharmacy cost
- $0.925 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 1
Highlights of the amoxicillin record
Amoxicillin (Amoxil) · label of February 22, 2024
Used for
From the label: indicationsAdults and Pediatric Patients • Upper Respiratory Tract Infections of the Ear, Nose, and Throat Amoxicillin is indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species. (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp. , or Haemophilus influenzae. […]
On the market
- Earliest approval on file
- January 18, 1974
- Generic labelers
- 38 labelers
- Pharmacy cost
- $0.0788 per capsule
Supply and safety
- Shortage
- No current entry
- Recalls
- 12
Source: FDA drug labels via openFDA (Cefprozil label of May 5, 2024, Amoxicillin label of February 22, 2024); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do cefprozil and amoxicillin differ on the record?
In FDA's classes, cefprozil is a cephalosporin antibacterial and amoxicillin a penicillin-class antibacterial.
Half-life, in each label's words: Cefprozil, “The average plasma half-life in normal subjects was 1.3 hours, while the steady-state volume of distribution was …”; Amoxicillin, “Metabolism and Excretion The half-life of amoxicillin is 61.3 minutes.”
Generics: cefprozil since 2005; amoxicillin since 1974 (Drugs@FDA).
| Cefprozil | Amoxicillin | |
|---|---|---|
| Labeled for | Bacterial infections | Bacterial infections, Acid reflux and ulcers |
| Pharmacologic class | Cephalosporin Antibacterial | Penicillin-class Antibacterial |
| How it works (label) | n/a | Amoxicillin is an antibacterial drug [see Microbiology ( 12.4 )]. |
| Half-life (label) | The average plasma half-life in normal subjects was 1.3 hours, while the steady-state volume of distribution was estimated to be 0.23 L/kg. | Metabolism and Excretion The half-life of amoxicillin is 61.3 minutes. |
| Earliest approval on file (Drugs@FDA) | December 23, 1991 | January 18, 1974 |
| First generic approved | November 14, 2005 | December 9, 1974 |
| Generic labelers (NDC) | 7 labelers | 38 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.925 per tablet (Cefprozil 500 mg tablet) | $0.0788 per capsule (Amoxicillin 500 mg capsule) |
| 12-month price change | -11% | -12% |
| Boxed warning | No | No |
| Shortage now | No current entry | No current entry |
| Recalls recorded | 1 | 12 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 780 | 75,926 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to cefprozil
- every medicine labeled for the same conditions