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Prescription medicine

Calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate

Calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate is a prescription medicine with an FDA approval on record since 1971. FDA's NDC Directory lists it from 1 generic labeler.

  • Generic listed

Check it at the source: the calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate FDA label on DailyMed (effective October 30, 2025, ICU Medical Inc.); the NDA 16679 record on Drugs@FDA; every calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate label on DailyMed.

Highlights of the record

FDA label of October 30, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026

Used for

From the label: indications and usage

This solution is indicated in patients requiring parenteral administration of potassium chloride and the replacement of extracellular losses of fluids and electrolytes with minimal carbohydrate calories.

Forms and strengths

  • 1.79 g/1000ml / 6 g/1000ml / 0.2 g/1000ml / 3.1 g/1000ml / 50 g/1000ml
  • 5 g/100ml / 310 mg/100ml / 600 mg/100ml / 30 mg/100ml / 20 mg/100ml
  • 5 g/100ml / 600 mg/100ml / 310 mg/100ml / 30 mg/100ml / 20 mg/100ml
  • 5 g/100ml / 600 mg/100ml / 310 mg/100ml / 179 mg/100ml / 20 mg/100ml
  • 5 g/100ml / 0.6 g/100ml / 0.31 g/100ml / 0.03 g/100ml / 0.02 g/100ml
  • 600 mg/100ml / 310 mg/100ml / 30 mg/100ml / 20 mg/100ml / 5 g/100ml

Injection (solution).

On the market

Earliest approval on file
March 22, 1971 Lactated Ringer'S And Dextrose 5% In Plastic Container, Baxter Hlthcare; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals
2 first November 9, 2021; 1 with a marketed status in Drugs@FDA
Labelers listed (NDC)
5 of which 1 under generic applications, 4 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC)
Not in the survey
Shortage (FDA)
No current entry
Recalls by its makers (FDA)
No recall recorded
FAERS reports
29 through July 30, 2026

What is calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate used for?

From the label: indications and usage

This solution is indicated in patients requiring parenteral administration of potassium chloride and the replacement of extracellular losses of fluids and electrolytes with minimal carbohydrate calories.

FDA pharmacologic class: Blood Coagulation Factor, Osmotic Laxative, Phosphate Binder and Potassium Salt.

Source: FDA drug label (Potassium Chloride in Lactated Ringers and Dextrose), NDA019685 (Otsuka Icu Medcl), as published by ICU Medical Inc., effective October 30, 2025 (SPL set 237b39fa-916e-4a54-99c8-4ae9ad54f056), via openFDA; the full label on DailyMed

Is there a generic for calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate?

The FDA approved the first generic calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate on November 9, 2021. 2 generic applications are approved; 1 of them carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate from 1 labeler under a generic (ANDA) application and from 4 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

  • 1971 earliest approval on file
  • 2021 first generic approved

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What does the calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate label say about other medicines?

The calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate label names 5 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Medicine namedSectionWhat the label says
Argininedrug interactionsThese drugs include diuretics and those that cause SIADH (e.g., arginine vasopressin analogs, certain antiepileptic, psychotropic, or cytotoxic drugs).
CeftriaxonecontraindicationsCONTRAINDICATIONS Lactated Ringer’s and Dextrose (5%) Injection is contraindicated in: Neonates (28 days of age or younger) who are receiving concomitant treatment with ceftriaxone, even if separate infusion lines are used, due to the risk of fatal ceftriaxone-calcium salt precipitation in the neonate’s bloodstream …
Corticotropindrug interactionsHypernatremia and Fluid Retention Administration of Lactated Ringer’s and Dextrose (5%) Injection to patients treated concomitantly with drugs associated with sodium and fluid retention (e.g., corticosteroids or corticotropin) may increase the risk of hypernatremia and volume overload.
Digoxindrug interactionsConsider reducing the volume or rate of Lactated Ringer’s and Dextrose (5%) Injection due to the increased risk of digoxin toxicity with calcium-containing solutions. ( 7.3 ) Drugs with pH-Dependent Renal Elimination:
Lithiumdrug interactionsIf concomitant use is unavoidable monitor serum lithium concentrations more frequently.

Check calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate against other medicines

Source: FDA drug label (Potassium Chloride in Lactated Ringers and Dextrose), NDA019685 (Otsuka Icu Medcl), as published by ICU Medical Inc., effective October 30, 2025 (SPL set 237b39fa-916e-4a54-99c8-4ae9ad54f056), via openFDA; the full label on DailyMed

What do FAERS reports show for calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate?

The FDA Adverse Event Reporting System holds 29 reports that list calcium chloride, dextrose, potassium chloride, sodium chloride and sodium lactate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 2 are coded as a death and 13 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

The most reported reactions

  • Dyspnoea3
  • No Adverse Event (a use or a product term, not a reaction)3
  • Abdominal Pain (named in the label)2
  • Anaesthetic Complication2
  • Chills2
  • Choking2
  • Cholecystitis Chronic2
  • Death (an outcome recorded in the report)2

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What next?

Other blood coagulation factors
the pharmacologic class, with prices and generics
Check an interaction
what two or more labels say about each other