Prescription medicine
Benzoyl peroxide and erythromycin Brand names: Benzamycin
Benzoyl peroxide and erythromycin (Benzamycin) is a prescription medicine with an FDA approval on record since 1984. FDA's NDC Directory lists it from 1 generic labeler, and pharmacies paid $1.32 per gram (Erythromycin-benzoyl gel) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the benzoyl peroxide and erythromycin FDA label on DailyMed (effective June 3, 2019, Oceanside Pharmaceuticals); the NDA 50557 record on Drugs@FDA; every benzoyl peroxide and erythromycin label on DailyMed.
Highlights of the record
FDA label of June 3, 2019; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageErythromycin-Benzoyl Peroxide Topical Gel is indicated for the topical treatment of acne vulgaris.
Forms and strengths
- 30 mg/g / 50 mg/g
Kit; gel.
On the market
- Earliest approval on file
- October 26, 1984 Benzamycin, Valeant Intl; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 2 first March 29, 2004; 1 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 3 of which 1 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $1.32 per gram Erythromycin-benzoyl gel
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 162 through July 30, 2026
What is benzoyl peroxide and erythromycin used for?
From the label: indications and usageErythromycin-Benzoyl Peroxide Topical Gel is indicated for the topical treatment of acne vulgaris.
Conditions named in the indications of benzoyl peroxide and erythromycin's FDA labels, with every medicine labeled for each:
From other benzoyl peroxide and erythromycin labelsAcne: INDICATIONS AND USAGE Erythromycin-Benzoyl Peroxide Topical Gel is indicated for the topical treatment of acne vulgaris.
FDA pharmacologic class: Macrolide and Macrolide Antimicrobial.
Source: FDA drug label (Erythromycin and Benzoyl Peroxide), NDA050557 (Valeant Intl), as published by Oceanside Pharmaceuticals, effective June 3, 2019 (SPL set be5bce27-bbb7-4503-b609-d89a77ee1e05), via openFDA; the full label on DailyMed
Is there a generic for benzoyl peroxide and erythromycin (Benzamycin)?
The FDA approved the first generic benzoyl peroxide and erythromycin on March 29, 2004. 2 generic applications are approved; 1 of them carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists benzoyl peroxide and erythromycin from 1 labeler under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1984 earliest approval on file
- 2004 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for benzoyl peroxide and erythromycin (Benzamycin)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $1.32 per gram (Erythromycin-benzoyl gel), up 6% from $1.24 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Erythromycin-benzoyl gel (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Erythromycin-benzoyl gel | Generic | $1.32 per gram | n/a | +6% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for benzoyl peroxide and erythromycin?
The FDA Adverse Event Reporting System holds 162 reports that list benzoyl peroxide and erythromycin among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 4 are coded as a death and 31 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as benzoyl peroxide and erythromycin?
9 other medicines are given the same way (topical) and in the same FDA class as benzoyl peroxide and erythromycin or labeled mainly for the same use (acne), the same class first. Acne lists all 26 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (topical) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Salicylic acid | Acne | none listed | $0.102 per patch Callus removers patch | No current entry |
| Sulfur | Acne | none listed | n/a | No current entry |
| Tretinoin | Acne | 19 labelers | $0.506 per gram 0.025% cream | No current entry |
| Adapalene | Acne | 34 labelers | $0.504 per gram 0.3% gel | No current entry |
| Dapsone | Acne | 16 labelers | $0.664 per gram 5% gel | A presentation being discontinued |
| Azelaic acid | Acne | 5 labelers | $0.441 per gram 15% gel | No current entry |
| Clindamycin and tretinoin | Acne | 3 labelers | $3.91 per gram 1.2%-0.025% | No current entry |
| Clascoterone | Acne | none listed | $10.00 per gram 1% cream | No current entry |
Every medicine labeled for the same conditions as benzoyl peroxide and erythromycin
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to benzoyl peroxide and erythromycin
- 9 medicines for the same use
- Other macrolides
- the pharmacologic class, with prices and generics
- Benzoyl peroxide and erythromycin side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other