Prescription medicine
Benzoyl peroxide and clindamycin Brand names: Onexton, Acanya, Neuac; first approved as Benzaclin
Benzoyl peroxide and clindamycin (Benzaclin) is a prescription medicine with an FDA approval on record since 2000. FDA's NDC Directory lists it from 12 generic labelers, and pharmacies paid $0.622 per gram (Clindamycin-benzoyl perox 1-5%) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the benzoyl peroxide and clindamycin FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA); the NDA 50756 record on Drugs@FDA; every benzoyl peroxide and clindamycin label on DailyMed.
Highlights of the record
FDA label of January 31, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageClindamycin and Benzoyl Peroxide Gel is indicated for the topical treatment of acne vulgaris.
Forms and strengths
- 10 mg/g / 50 mg/g
- 10 mg/g / 37.5 mg/g
- 10 mg/g / 25 mg/g
- 25 mg/g / 10 mg/g
Gel; kit.
On the market
- Earliest approval on file
- December 21, 2000 Benzaclin, Bausch; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 17 first August 11, 2009; 15 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 14 of which 12 under generic applications, 1 under brand applications, repackagers included
- Last listed patent
- August 5, 2029 Acanya gel; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $0.622 per gram Clindamycin-benzoyl perox 1-5%
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 3 since 2013 0 Class I among all firms' recalls; latest November 8, 2021
- FAERS reports
- 598 through July 30, 2026
What is benzoyl peroxide and clindamycin used for?
From the label: indications and usageClindamycin and Benzoyl Peroxide Gel is indicated for the topical treatment of acne vulgaris.
Conditions named in the indications of benzoyl peroxide and clindamycin's FDA labels, with every medicine labeled for each:
From other benzoyl peroxide and clindamycin labelsAcne: INDICATIONS AND USAGE Clindamycin and Benzoyl Peroxide Gel is indicated for the topical treatment of acne vulgaris.
FDA pharmacologic class: Lincosamide Antibacterial.
Source: FDA drug label (clindamycin and benzoyl peroxide), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 76795d1b-e1f2-4d1d-b42a-f1d4448c63c0), via openFDA; the full label on DailyMed
What does the patient leaflet for benzoyl peroxide and clindamycin say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What should I avoid while using ONEXTON Gel?Limit your time in sunlight. You should avoid using tanning beds or sun lamps during treatment with ONEXTON Gel. If you have to be in sunlight, wear a wide-brimmed hat or other protective clothing, and use sunscreen to cover the treated areas. • Avoid getting ONEXTON Gel in your hair or on colored fabric. ONEXTON Gel may bleach hair or colored fabric.
From the patient leaflet: How should I store ONEXTON Gel?Store ONEXTON Gel at room temperature at or below 77°F (25°C). • Do not freeze ONEXTON Gel. • Throw away (discard) ONEXTON Gel 8 weeks after date of dispensing. • Store pump upright. • Keep the container tightly closed. Keep ONEXTON Gel and all medicines out of the reach of children.
Source: FDA drug label (ONEXTON), Bausch Health US, LLC, effective July 23, 2025 (SPL set 697e760a-c206-4565-8f4e-a8085e215827), via openFDA; the full label on DailyMed
Is there a generic for benzoyl peroxide and clindamycin (Benzaclin)?
The FDA approved the first generic benzoyl peroxide and clindamycin on August 11, 2009. 17 generic applications are approved; 15 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists benzoyl peroxide and clindamycin from 12 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
The Orange Book lists no patent for Benzaclin gel; a patent listed only for Acanya gel runs to August 5, 2029. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 2000 earliest approval on file
- 2009 first generic approved
- 2029 last listed patent
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for benzoyl peroxide and clindamycin (Benzaclin)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.622 per gram (Clindamycin-benzoyl perox 1-5%), down 14% from $0.726 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Clindamycin-benzoyl perox 1-5% (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Clind ph-benzoyl pero 1.2-2.5% | Generic | $0.819 per gram | n/a | -17% |
| Clind ph-benzoyl perox 1.2-5% | Generic | $0.411 per gram | n/a | -18% |
| Clindamyc-bnz perox 1.2-3.75% | Generic | $2.34 per gram | n/a | -36% |
| Clindamycin-benzoyl perox 1-5% | Generic | $0.622 per gram | n/a | -14% |
| Clindamycin-bnz perox 1-5% pmp | Generic | $1.01 per gram | n/a | -4% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has benzoyl peroxide and clindamycin been recalled?
The FDA's Enforcement Report lists 3 recalls naming benzoyl peroxide and clindamycin since 2013: 0 Class I (the most serious), 2 Class II, 1 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| November 8, 2021 | Class II | TOLMAR, Inc. | Superpotent Drug |
| December 28, 2016 | Class II | L. Perrigo Company | Microbial Contamination of Non-Sterile Product; small number of tubes may include the presence of mold on the cap |
| September 20, 2013 | Class III | Valeant Pharmaceuticals North Am | Labeling: Incorrect or Missing Lot and/or Exp Date: This recall is being carried out due to an incorrect expiration date assigned to a lot of physicians … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the benzoyl peroxide and clindamycin label say about other medicines?
The benzoyl peroxide and clindamycin label names 3 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Atropine | warnings | ANTIPERISTALTIC AGENTS SUCH AS OPIATES AND DIPHENOXYLATE WITH ATROPINE MAY PROLONG AND/OR WORSEN THE CONDITION. |
| Erythromycin | drug interactions | In vitro studies have shown antagonism between erythromycin and clindamycin. |
| Lincomycin | contraindications | CONTRAINDICATIONS Clindamycin and Benzoyl Peroxide Gel is contraindicated in those individuals who have shown hypersensitivity to any of its components or to lincomycin. |
Check benzoyl peroxide and clindamycin against other medicines
Source: FDA drug label (clindamycin and benzoyl peroxide), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 76795d1b-e1f2-4d1d-b42a-f1d4448c63c0), via openFDA; the full label on DailyMed
What do FAERS reports show for benzoyl peroxide and clindamycin?
The FDA Adverse Event Reporting System holds 598 reports that list benzoyl peroxide and clindamycin among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 3 are coded as a death and 43 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as benzoyl peroxide and clindamycin?
8 other medicines are given the same way (topical) and in the same FDA class as benzoyl peroxide and clindamycin or labeled mainly for the same use (acne), the same class first. Acne lists all 26 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (topical) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Salicylic acid | Acne | none listed | $0.102 per patch Callus removers patch | No current entry |
| Sulfur | Acne | none listed | n/a | No current entry |
| Tretinoin | Acne | 19 labelers | $0.506 per gram 0.025% cream | No current entry |
| Adapalene | Acne | 34 labelers | $0.504 per gram 0.3% gel | No current entry |
| Dapsone | Acne | 16 labelers | $0.664 per gram 5% gel | A presentation being discontinued |
| Azelaic acid | Acne | 5 labelers | $0.441 per gram 15% gel | No current entry |
| Clascoterone | Acne | none listed | $10.00 per gram 1% cream | No current entry |
| Trifarotene | Acne | none listed | $16.36 per gram 0.005% cream | No current entry |
Every medicine labeled for the same conditions as benzoyl peroxide and clindamycin
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to benzoyl peroxide and clindamycin
- 8 medicines for the same use
- Other lincosamide antibacterials
- the pharmacologic class, with prices and generics
- Benzoyl peroxide and clindamycin side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other