FDA pharmacologic class
Endoglycosidase
1 medicine is in FDA's class of endoglycosidases: hyaluronidase (Hylenex); 10 combination products also contain one. 0 of the 11 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is hylenex 150 units/ml vial at $53.69 per mL (NADAC).
Which medicines are endoglycosidase?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Amivantamab and hyaluronidase | Rybrevant | none listed | n/a | No | No current entry | 0 |
| Hyaluronidase | Amphadase, Hylenex | none listed | $53.69 per mL 150 units/mL vial | No | No current entry | 1 |
| Berahyaluronidase alfa and pembrolizumab | Keytruda | none listed | n/a | No | No current entry | 0 |
| Efgartigimod alfa and hyaluronidase | Vyvgart | none listed | n/a | No | No current entry | 0 |
| Hyaluronidase and nivolumab | Opdivo | none listed | n/a | No | No current entry | 0 |
| Hyaluronidase and pertuzumab and trastuzumab | Phesgo | none listed | n/a | Yes | No current entry | 0 |
| Hyaluronidase and rituximab | Rituxan | none listed | n/a | Yes | No current entry | 0 |
| Atezolizumab and hyaluronidase | Tecentriq | none listed | n/a | No | No current entry | 0 |
| Daratumumab and hyaluronidase | Darzalex | none listed | n/a | No | No current entry | 0 |
| Hyaluronidase and ocrelizumab | Ocrevus | none listed | n/a | No | No current entry | 0 |
| Hyaluronidase and trastuzumab | Herceptin | none listed | n/a | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price