Drug side effects
vilazodone Side Effects
The reactions most often reported to the FDA for vilazodone (also sold as Viibryd), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 9,764
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2009 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of vilazodone come from 9,764 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 9,764 reports to the FDA Adverse Event Reporting System (FAERS) for vilazodone (Viibryd): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
9,764
Reports Mentioning Death
328
3.4% of reports — not proof the medicine caused the death
Hospitalizations
1,195
12.2% of reports
Top Indication
Depression
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 328 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 174 |
| DEATH | 77 |
| TOXICITY TO VARIOUS AGENTS | 38 |
| CARDIO-RESPIRATORY ARREST | 22 |
| CARDIAC ARREST | 15 |
| OVERDOSE | 15 |
| SUSPECTED SUICIDE | 13 |
| RESPIRATORY ARREST | 10 |
| ACUTE KIDNEY INJURY | 8 |
| GUN SHOT WOUND | 8 |
| INTENTIONAL OVERDOSE | 8 |
| FATIGUE | 7 |
| HYPERTHERMIA | 6 |
| HYPOTENSION | 6 |
| NAUSEA | 6 |
| PNEUMONIA | 6 |
| PULMONARY OEDEMA | 6 |
| RENAL FAILURE | 6 |
| BRADYCARDIA | 5 |
Reactions in Hospitalization Reports
Top reactions in 1,195 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| NAUSEA | 90 |
| ANXIETY | 86 |
| DEPRESSION | 79 |
| SEROTONIN SYNDROME | 79 |
| SUICIDAL IDEATION | 74 |
| FALL | 73 |
| HEADACHE | 73 |
| VOMITING | 68 |
| FATIGUE | 64 |
| PAIN | 61 |
| DIARRHOEA | 60 |
| DIZZINESS | 53 |
| SUICIDE ATTEMPT | 52 |
| DYSPNOEA | 48 |
| ASTHENIA | 46 |
| OVERDOSE | 46 |
| TREMOR | 43 |
| HOSPITALISATION | 42 |
Nearby, Related Medications
What the FAERS Data Reveals About vilazodone Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 9,764 voluntary reports linked to vilazodone and its brand equivalents (Viibryd), spanning 2009 through 2025. Of those, 328 (3.4%) listed death as an outcome and 1,195 (12.2%) involved hospitalization. The most common indication reported alongside adverse events was Depression.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 72% were female and 28% male; age distribution skews toward 45-64, with 2,351 reports in that bracket. The single most reported reaction is diarrhoea with 808 submissions, followed by nausea and anxiety.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to vilazodone's 9,764.
Read our methodology - how this data is sourced, computed, and verified.