HIGH-VOLUME · SEX-BALANCED
venlafaxine Side Effects
venlafaxine (also sold as Effexor, Effexor XR) is HIGH-VOLUME in this FAERS book #108 of 524 by FAERS report count. Signature opener: SEX-BALANCED - 68% of sex-coded reports are female (41,669 F / 19,392 M).
Data updated 2026-05-15
- 68,147
- FAERS reports
FAERS voluntary reports, 2002 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
venlafaxine reporting skew - 68% of sex-coded reports are female (41,669 F / 19,392 M). Volume band HIGH-VOLUME #108 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for venlafaxine (Effexor): 68,147 FAERS rows (2002-2025). Top named reactions: NAUSEA, TOXICITY TO VARIOUS AGENTS, FATIGUE. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2002–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
NAUSEA leads 4,298 of 68,147 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (19,690 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (9,746 reports, 14.3%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 3,149 |
| TOXICITY TO VARIOUS AGENTS | 2,336 |
| DEATH | 1,712 |
| CARDIO-RESPIRATORY ARREST | 876 |
| OVERDOSE | 660 |
| DRUG ABUSE | 611 |
| CARDIAC ARREST | 570 |
| DRUG INTERACTION | 469 |
| FALL | 402 |
| DYSPNOEA | 379 |
| HEADACHE | 378 |
| FATIGUE | 373 |
| DIARRHOEA | 341 |
| VOMITING | 340 |
| COMA | 329 |
| PYREXIA | 327 |
| RESPIRATORY ARREST | 322 |
| SEPSIS | 310 |
| NAUSEA | 309 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (24,846, 36.5% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| TOXICITY TO VARIOUS AGENTS | 2,059 |
| INTENTIONAL OVERDOSE | 1,623 |
| DRUG INTERACTION | 1,404 |
| OVERDOSE | 1,370 |
| SUICIDE ATTEMPT | 1,311 |
| FALL | 1,271 |
| NAUSEA | 1,216 |
| SEROTONIN SYNDROME | 1,213 |
| FATIGUE | 1,145 |
| VOMITING | 1,099 |
| DYSPNOEA | 1,074 |
| HYPOTENSION | 1,052 |
| DIARRHOEA | 1,026 |
| ACUTE KIDNEY INJURY | 918 |
| HEADACHE | 900 |
| COMA | 897 |
| DEPRESSION | 880 |
| COMPLETED SUICIDE | 863 |
How to read venlafaxine FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 68,147 voluntary reports linked to venlafaxine (Effexor, Effexor XR), 2002-2025. Death is listed on 9,746 (14.3%). Hospitalization appears on 24,846 (36.5%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; SEX-BALANCED is the page opener, not a per-patient risk.
Read with venlafaxine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 68,257 FAERS cases (Δ 110 heavier vs venlafaxine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 67,703 FAERS cases (Δ 444 lighter vs venlafaxine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 70,203 FAERS cases (Δ 2,056 heavier vs venlafaxine); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 70,292 FAERS cases (Δ 2,145 heavier vs venlafaxine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 47.8 pp vs venlafaxine's DEATH-HEAVY): CASELOAD · HOSP-MID.
venlafaxine stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.