LOW-VOLUME · FEMALE-LED
propylthiouracil Side Effects
propylthiouracil (also sold as PTU) is a LOW-VOLUME FAERS extract #459 of 524 by FAERS report count. Still opens on FEMALE-LED: 74% of sex-coded reports are female (1,283 F / 460 M).
Data updated 2026-05-15
- 1,982
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
propylthiouracil reporting skew - 74% of sex-coded reports are female (1,283 F / 460 M). Volume band LOW-VOLUME #459 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for propylthiouracil (PTU) (1,982 reports #459 of 524 by FAERS report count). 74% of sex-coded reports are female (1,283 F / 460 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
HYPERTHYROIDISM leads 135 of 1,982 reports
FEMALE-LED reporters · age peak 18-44
Female-led reporters (74% of sex-coded rows)
Age peak 18-44 (577 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (170 reports, 8.6%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| CARDIAC ARREST | 23 |
| DEATH | 21 |
| MULTIPLE ORGAN DYSFUNCTION SYNDROME | 19 |
| ACUTE KIDNEY INJURY | 14 |
| RENAL FAILURE | 13 |
| CARDIAC FAILURE CONGESTIVE | 11 |
| ACUTE HEPATIC FAILURE | 10 |
| PNEUMONIA | 10 |
| CIRCULATORY COLLAPSE | 9 |
| DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS | 9 |
| HYPERTHYROIDISM | 9 |
| HYPOTENSION | 9 |
| NAUSEA | 9 |
| SEPTIC SHOCK | 9 |
| CARDIOGENIC SHOCK | 8 |
| CHRONIC KIDNEY DISEASE | 8 |
| END STAGE RENAL DISEASE | 8 |
| THYROTOXIC CRISIS | 8 |
| CARDIO-RESPIRATORY ARREST | 7 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (907, 45.8% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| HYPERTHYROIDISM | 82 |
| HYPOTENSION | 49 |
| NAUSEA | 45 |
| AGRANULOCYTOSIS | 42 |
| PYREXIA | 41 |
| VOMITING | 36 |
| ACUTE KIDNEY INJURY | 35 |
| ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY POSITIVE VASCULITIS | 35 |
| THYROTOXIC CRISIS | 35 |
| ACUTE HEPATIC FAILURE | 33 |
| CARDIOGENIC SHOCK | 31 |
| CONDITION AGGRAVATED | 30 |
| PNEUMONIA | 30 |
| CARDIAC ARREST | 29 |
| DIARRHOEA | 28 |
| ANAEMIA | 27 |
| FATIGUE | 27 |
| FOETAL EXPOSURE DURING PREGNANCY | 26 |
How to read propylthiouracil FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 1,982 voluntary reports linked to propylthiouracil (PTU), 2004-2025. Death is listed on 170 (8.6%). Hospitalization appears on 907 (45.8%). Top co-reported indication: Hyperthyroidism.
Sparse extract - named reactions and FEMALE-LED skew still differ by drug; not a complete safety profile.
Read with propylthiouracil
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 1,978 FAERS cases (Δ 4 lighter vs propylthiouracil); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 1,963 FAERS cases (Δ 19 lighter vs propylthiouracil); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 2,013 FAERS cases (Δ 31 heavier vs propylthiouracil); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(total_reports) peer at 2,050 FAERS cases (Δ 68 heavier vs propylthiouracil); DEATH-MARKED · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 53.5 pp vs propylthiouracil's DEATH-HEAVY): CASELOAD · HOSP-MID.
propylthiouracil stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.