prazosin Side Effects
Also known as: Minipress
Analysis of 5,825 adverse event reports submitted to the FDA from 2001 to 2025.
Total Reports
5,825
Death-Related
676
11.6% of reports
Hospitalizations
2,125
36.5% of reports
Top Indication
Product Used For Unknown Indication
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 676 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 191 |
| DEATH | 111 |
| TOXICITY TO VARIOUS AGENTS | 100 |
| CARDIO-RESPIRATORY ARREST | 75 |
| DRUG INTERACTION | 50 |
| CARDIAC ARREST | 41 |
| NAUSEA | 40 |
| DECREASED APPETITE | 38 |
| VOMITING | 37 |
| OROPHARYNGEAL PAIN | 34 |
| SUDDEN CARDIAC DEATH | 33 |
| ANALGESIC DRUG LEVEL ABOVE THERAPEUTIC | 32 |
| ANTIDEPRESSANT DRUG LEVEL ABOVE THERAPEUTIC | 32 |
| ELECTROCARDIOGRAM QT PROLONGED | 32 |
| PULMONARY CONGESTION | 32 |
| SLEEP DISORDER | 32 |
| SUSPECTED SUICIDE | 30 |
| PNEUMONIA | 26 |
| FALL | 25 |
| ACUTE MYOCARDIAL INFARCTION | 21 |
Reactions in Hospitalization Reports
Top reactions in 2,125 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| TOXICITY TO VARIOUS AGENTS | 140 |
| HYPOTENSION | 128 |
| OFF LABEL USE | 128 |
| VOMITING | 110 |
| NAUSEA | 104 |
| FALL | 102 |
| DRUG INEFFECTIVE | 96 |
| DRUG INTERACTION | 92 |
| ANXIETY | 91 |
| DIARRHOEA | 91 |
| DYSPNOEA | 90 |
| ACUTE KIDNEY INJURY | 87 |
| SUICIDAL IDEATION | 86 |
| INTENTIONAL OVERDOSE | 85 |
| COMPLETED SUICIDE | 80 |
| OVERDOSE | 80 |
| PNEUMONIA | 77 |
| DEPRESSION | 75 |
| HEADACHE | 72 |
| DIZZINESS | 68 |
Nearby — Related Medications
What the FAERS Data Reveals About prazosin Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 5,825 voluntary reports linked to prazosin and its brand equivalents (Minipress), spanning 2001 through 2025. Of those, 676 (11.6%) listed death as an outcome and 2,125 (36.5%) involved hospitalization. The most common indication reported alongside adverse events was Product Used For Unknown Indication.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 57% were female and 43% male; age distribution skews toward 18-44, with 1,564 reports in that bracket. The single most reported reaction is drug ineffective with 388 submissions, followed by nausea and off label use.
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice — speak with a licensed clinician about any side-effect concerns.
Read our methodology — how this data is sourced, computed, and verified.