HIGH-VOLUME · HOSP-HEAVY
hydrochlorothiazide Side Effects
hydrochlorothiazide (also sold as Microzide) is HIGH-VOLUME in this FAERS book #46 of 524 by FAERS report count. Signature opener: HOSP-HEAVY - 34.5% mention hospitalization (48,508 reports).
Data updated 2026-05-15
- 140,497
- FAERS reports
FAERS voluntary reports, 1998 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
hydrochlorothiazide: 34.5% mention hospitalization (48,508 reports). Death stamp DEATH-HEAVY; volume band HIGH-VOLUME #46 of 524 by FAERS report count.
High-report extract for hydrochlorothiazide (Microzide): 140,497 FAERS rows (1998-2025). Top named reactions: FATIGUE, NAUSEA, DIARRHOEA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (1998–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
FATIGUE leads 10,014 of 140,497 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (36,305 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (9,873 reports, 7.0%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 2,955 |
| COMPLETED SUICIDE | 1,020 |
| DYSPNOEA | 718 |
| RENAL FAILURE | 603 |
| DIARRHOEA | 597 |
| SEPSIS | 597 |
| ACUTE KIDNEY INJURY | 592 |
| FATIGUE | 576 |
| CARDIO-RESPIRATORY ARREST | 568 |
| ASTHENIA | 545 |
| FALL | 513 |
| PNEUMONIA | 508 |
| NAUSEA | 476 |
| VOMITING | 473 |
| TOXICITY TO VARIOUS AGENTS | 435 |
| CARDIAC ARREST | 404 |
| PYREXIA | 404 |
| DIZZINESS | 395 |
| DECREASED APPETITE | 388 |
| CHRONIC KIDNEY DISEASE | 385 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (48,508, 34.5% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| NAUSEA | 3,745 |
| DYSPNOEA | 3,438 |
| FALL | 3,317 |
| FATIGUE | 3,124 |
| DIARRHOEA | 3,059 |
| PAIN | 2,957 |
| ACUTE KIDNEY INJURY | 2,941 |
| VOMITING | 2,821 |
| ASTHENIA | 2,760 |
| PNEUMONIA | 2,677 |
| DIZZINESS | 2,600 |
| HYPOTENSION | 2,458 |
| HYPONATRAEMIA | 2,352 |
| HEADACHE | 2,327 |
| HYPERTENSION | 2,178 |
| MALAISE | 2,172 |
| PYREXIA | 2,145 |
| DEHYDRATION | 1,983 |
| WEIGHT DECREASED | 1,919 |
How to read hydrochlorothiazide FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 140,497 voluntary reports linked to hydrochlorothiazide (Microzide), 1998-2025. Death is listed on 9,873 (7.0%). Hospitalization appears on 48,508 (34.5%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; HOSP-HEAVY is the page opener, not a per-patient risk.
Read with hydrochlorothiazide
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 143,174 FAERS cases (Δ 2,677 heavier vs hydrochlorothiazide); DEATH-MARKED · HOSP-LIGHT · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 134,536 FAERS cases (Δ 5,961 lighter vs hydrochlorothiazide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 134,198 FAERS cases (Δ 6,299 lighter vs hydrochlorothiazide); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 133,996 FAERS cases (Δ 6,501 lighter vs hydrochlorothiazide); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 55.1 pp vs hydrochlorothiazide's DEATH-HEAVY): CASELOAD · HOSP-MID.
hydrochlorothiazide stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.