HIGH-VOLUME · SEX-BALANCED
epinephrine Side Effects
epinephrine (also sold as EpiPen, Adrenalin) is HIGH-VOLUME in this FAERS book #120 of 524 by FAERS report count. Signature opener: SEX-BALANCED - 67% of sex-coded reports are female (35,449 F / 17,773 M).
Data updated 2026-05-15
- 61,536
- FAERS reports
FAERS voluntary reports, 1999 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
epinephrine reporting skew - 67% of sex-coded reports are female (35,449 F / 17,773 M). Volume band HIGH-VOLUME #120 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for epinephrine (EpiPen): 61,536 FAERS rows (1999-2025). Top named reactions: HEADACHE, SINUSITIS, FATIGUE. Outcome stamps DEATH-HEAVY · HOSP-MID · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (1999–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
HEADACHE leads 4,161 of 61,536 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (11,022 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (3,931 reports, 6.4%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 1,225 |
| CARDIAC ARREST | 480 |
| RENAL FAILURE | 380 |
| PAIN | 361 |
| HYPOTENSION | 307 |
| INJURY | 289 |
| PNEUMONIA | 282 |
| ANXIETY | 271 |
| UNEVALUABLE EVENT | 252 |
| FEAR | 216 |
| RESPIRATORY FAILURE | 211 |
| MULTI-ORGAN FAILURE | 209 |
| TOXICITY TO VARIOUS AGENTS | 205 |
| RENAL INJURY | 199 |
| DYSPNOEA | 197 |
| RENAL IMPAIRMENT | 191 |
| EMOTIONAL DISTRESS | 190 |
| ANHEDONIA | 185 |
Reactions in Hospitalization Reports
Hospitalization mid-share (16,914, 27.5%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| PNEUMONIA | 1,611 |
| DYSPNOEA | 1,453 |
| FATIGUE | 1,214 |
| PAIN | 1,172 |
| HEADACHE | 1,166 |
| COVID-19 | 1,111 |
| NAUSEA | 1,053 |
| SINUSITIS | 1,051 |
| FALL | 1,014 |
| HYPOTENSION | 938 |
| URINARY TRACT INFECTION | 910 |
| PYREXIA | 832 |
| VOMITING | 829 |
| INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION | 819 |
| WEIGHT DECREASED | 735 |
| COUGH | 725 |
| MALAISE | 712 |
How to read epinephrine FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-MID)
FAERS holds 61,536 voluntary reports linked to epinephrine (EpiPen, Adrenalin), 1999-2025. Death is listed on 3,931 (6.4%). Hospitalization appears on 16,914 (27.5%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; SEX-BALANCED is the page opener, not a per-patient risk.
Read with epinephrine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 61,560 FAERS cases (Δ 24 heavier vs epinephrine); DEATH-MARKED · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 60,533 FAERS cases (Δ 1,003 lighter vs epinephrine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 62,650 FAERS cases (Δ 1,114 heavier vs epinephrine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 59,560 FAERS cases (Δ 1,976 lighter vs epinephrine); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 55.7 pp vs epinephrine's DEATH-HEAVY): CASELOAD · HOSP-MID.
epinephrine stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.