LOW-VOLUME · FEMALE-LED
desipramine Side Effects
desipramine (also sold as Norpramin) is a LOW-VOLUME FAERS extract #480 of 524 by FAERS report count. Still opens on FEMALE-LED: 71% of sex-coded reports are female (816 F / 338 M).
Data updated 2026-05-15
- 1,275
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
desipramine reporting skew - 71% of sex-coded reports are female (816 F / 338 M). Volume band LOW-VOLUME #480 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for desipramine (Norpramin) (1,275 reports #480 of 524 by FAERS report count). 71% of sex-coded reports are female (816 F / 338 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
FATIGUE leads 119 of 1,275 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (71% of sex-coded rows)
Age peak 45-64 (385 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (217 reports, 17.0%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 116 |
| TOXICITY TO VARIOUS AGENTS | 58 |
| DEATH | 36 |
| CARDIO-RESPIRATORY ARREST | 18 |
| DYSPNOEA | 17 |
| OVERDOSE | 17 |
| LOSS OF CONSCIOUSNESS | 16 |
| CONFUSIONAL STATE | 13 |
| CARDIAC ARREST | 12 |
| ANTIDEPRESSANT DRUG LEVEL ABOVE THERAPEUTIC | 11 |
| DRUG INTERACTION | 10 |
| SUSPECTED SUICIDE | 10 |
| RESPIRATORY ARREST | 8 |
| NEUROLEPTIC MALIGNANT SYNDROME | 7 |
| DRUG ABUSE | 6 |
| RENAL FAILURE | 6 |
| DRUG LEVEL INCREASED | 5 |
| VENTRICULAR FIBRILLATION | 5 |
| ACCIDENT | 4 |
Reactions in Hospitalization Reports
Hospitalization mid-share (341, 26.7%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| ACUTE KIDNEY INJURY | 28 |
| FATIGUE | 23 |
| HEADACHE | 23 |
| DYSPNOEA | 22 |
| DIZZINESS | 21 |
| FALL | 21 |
| NAUSEA | 21 |
| PAIN | 21 |
| COMPLETED SUICIDE | 20 |
| INTESTINAL OBSTRUCTION | 20 |
| URINARY RETENTION | 19 |
| WEIGHT DECREASED | 19 |
| ANXIETY | 18 |
| CHEST PAIN | 18 |
| LOSS OF CONSCIOUSNESS | 17 |
| ABDOMINAL PAIN | 16 |
| DEPRESSION | 16 |
| ILEUS | 16 |
How to read desipramine FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-MID)
FAERS holds 1,275 voluntary reports linked to desipramine (Norpramin), 2004-2025. Death is listed on 217 (17.0%). Hospitalization appears on 341 (26.7%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and FEMALE-LED skew still differ by drug; not a complete safety profile.
Read with desipramine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 1,256 FAERS cases (Δ 19 lighter vs desipramine); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,302 FAERS cases (Δ 27 heavier vs desipramine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,220 FAERS cases (Δ 55 lighter vs desipramine); DEATH-MARKED · HOSP-HEAVY · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 1,205 FAERS cases (Δ 70 lighter vs desipramine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 45.1 pp vs desipramine's DEATH-HEAVY): CASELOAD · HOSP-MID.
desipramine stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.