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PlainMeds

Prescription medicine

Cupric sulfate, manganese sulfate, selenious acid and zinc sulfate Brand names: Multrys, Tralement

Cupric sulfate, manganese sulfate, selenious acid and zinc sulfate (Tralement) is a prescription medicine with an FDA approval on record since 2020. No generic is listed in FDA's NDC Directory.

  • No generic listed

Check it at the source: the cupric sulfate, manganese sulfate, selenious acid and zinc sulfate FDA label on DailyMed (effective July 1, 2024, American Regent, Inc.); the NDA 209376 record on Drugs@FDA; every cupric sulfate, manganese sulfate, selenious acid and zinc sulfate label on DailyMed.

Highlights of the record

FDA label of July 1, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026

Used for

From the label: indications and usage

Tralement ® is indicated in adult and pediatric patients weighing at least 10 kg as a source of zinc, copper, manganese, and selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

Forms and strengths

  • 3 mg/ml / 0.3 mg/ml

Injection (solution).

On the market

Earliest approval on file
July 2, 2020 Multrys, Am Regent; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals
No generic approved
Labelers listed (NDC)
1 of which 0 under generic applications, 1 under brand applications, repackagers included
Last listed patent
July 1, 2041 Tralement injection; not a generic launch date

Supply and safety

Pharmacy cost (NADAC)
Not in the survey
Shortage (FDA)
No current entry
Recalls by its makers (FDA)
No recall recorded
FAERS reports
8 through July 30, 2026

What is cupric sulfate, manganese sulfate, selenious acid and zinc sulfate used for?

From the label: indications and usage

Tralement ® is indicated in adult and pediatric patients weighing at least 10 kg as a source of zinc, copper, manganese, and selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Tralement is a combination of trace elements (zinc sulfate, cupric sulfate, manganese sulfate and selenious acid) indicated in adult and pediatric patients weighing at least 10 kg as a source of zinc, copper, manganese, and selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

FDA pharmacologic class: Copper Absorption Inhibitor and Paramagnetic Contrast Agent.

Source: FDA drug label (Tralement), American Regent, Inc., effective July 1, 2024 (SPL set a49ffb90-f307-433e-a86e-aaea6d6a9982), via openFDA; the full label on DailyMed

Is there a generic for cupric sulfate, manganese sulfate, selenious acid and zinc sulfate (Tralement)?

No generic cupric sulfate, manganese sulfate, selenious acid and zinc sulfate is approved (Drugs@FDA, October 8, 2026).

The Orange Book lists 5 patents for Tralement injection, the last expiring on July 1, 2041. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.

  • 2020 earliest approval on file
  • 2041 last listed patent

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What do FAERS reports show for cupric sulfate, manganese sulfate, selenious acid and zinc sulfate?

The FDA Adverse Event Reporting System holds 8 reports that list cupric sulfate, manganese sulfate, selenious acid and zinc sulfate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 1 are coded as a death and 4 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

The most reported reactions

  • Product Label Confusion3
  • Anaemia2
  • Diarrhoea2
  • Infection2
  • Muscular Weakness2
  • Physical Product Label Issue2
  • Product Dose Omission Issue (a use or a product term, not a reaction)2
  • Pyrexia2

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What next?

Other copper absorption inhibitors
the pharmacologic class, with prices and generics
Check an interaction
what two or more labels say about each other