MID-VOLUME · DEATH-HEAVY
aflibercept Side Effects
aflibercept (also sold as Eylea) sits MID-VOLUME #191 of 524 by FAERS report count. Lead signal: DEATH-HEAVY - 29.6% of FAERS reports list death as an outcome (8,845 of 29,874). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 29,874
- FAERS reports
FDA Adverse Event Reporting System extract for aflibercept. Stamp set CASELOAD · DEATH-HEAVY · HOSP-MID. How figures are compiled.
aflibercept: 29.6% of FAERS reports list death as an outcome (8,845 of 29,874). Caseload stamp CASELOAD; volume band MID-VOLUME #191 of 524 by FAERS report count.
Mid-book FAERS page for aflibercept (Eylea) (29,874 reports). Signature DEATH-HEAVY. Dominant age band on file: 75+. Educational reference only.
Counts from the openFDA FAERS extract (2007–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
DEATH leads 7,853 of 29,874 reports
Who reports · age peak 75+ (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 75+ (2,827 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (8,845 reports, 29.6%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 7,846 |
| MYOCARDIAL INFARCTION | 95 |
| CEREBROVASCULAR ACCIDENT | 71 |
| DIARRHOEA | 71 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 60 |
| NEOPLASM MALIGNANT | 47 |
| PNEUMONIA | 47 |
| DISEASE PROGRESSION | 44 |
| RENAL FAILURE | 43 |
| SEPSIS | 38 |
| ASTHENIA | 37 |
| FATIGUE | 37 |
| FALL | 36 |
| VOMITING | 34 |
| NEUTROPENIA | 33 |
| ANAEMIA | 31 |
| HYPERTENSION | 30 |
| DYSPNOEA | 29 |
Reactions in Hospitalization Reports
Hospitalization mid-share (3,872, 13.0%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| HOSPITALISATION | 309 |
| DIARRHOEA | 214 |
| ENDOPHTHALMITIS | 214 |
| VISUAL IMPAIRMENT | 200 |
| FALL | 162 |
| CEREBROVASCULAR ACCIDENT | 152 |
| BLINDNESS | 144 |
| HYPERTENSION | 141 |
| EYE PAIN | 133 |
| ASTHENIA | 120 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 113 |
| PNEUMONIA | 112 |
| VISION BLURRED | 111 |
| VOMITING | 109 |
| MALAISE | 108 |
| MYOCARDIAL INFARCTION | 108 |
| VISUAL ACUITY REDUCED | 107 |
| PYREXIA | 106 |
| DYSPNOEA | 99 |
How to read aflibercept FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-MID)
FAERS holds 29,874 voluntary reports linked to aflibercept (Eylea), 2007-2025. Death is listed on 8,845 (29.6%). Hospitalization appears on 3,872 (13.0%). Top co-reported indication: Product Used For Unknown Indication.
Mid-volume extract - treat DEATH-HEAVY · HOSP-MID as signal-detection rates next to 29.6% of FAERS reports list death as an outcome (8,845 of 29,874).
Read with aflibercept
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 29,879 FAERS cases (Δ 5 heavier vs aflibercept); DEATH-MARKED · HOSP-MID · FEMALE-LED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 29,813 FAERS cases (Δ 61 lighter vs aflibercept); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 30,089 FAERS cases (Δ 215 heavier vs aflibercept); DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 29,554 FAERS cases (Δ 320 lighter vs aflibercept); DEATH-MARKED · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 32.5 pp vs aflibercept's DEATH-HEAVY): CASELOAD · HOSP-MID.
aflibercept stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.