Drug side effects
benzoyl peroxide Side Effects
The reactions most often reported to the FDA for benzoyl peroxide (also sold as Benzac, PanOxyl), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 6,624
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2004 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of benzoyl peroxide come from 6,624 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 6,624 reports to the FDA Adverse Event Reporting System (FAERS) for benzoyl peroxide (Benzac): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
6,624
Reports Mentioning Death
51
0.8% of reports — not proof the medicine caused the death
Hospitalizations
370
5.6% of reports
Top Indication
Acne
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 51 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| CEREBRAL ISCHAEMIA | 11 |
| DEATH | 11 |
| EMBOLISM | 11 |
| POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME | 11 |
| PNEUMONIA | 8 |
| PANCREATIC CARCINOMA | 7 |
| PAIN | 6 |
| DYSPNOEA | 5 |
| NEOPLASM PROGRESSION | 5 |
| COMPLETED SUICIDE | 4 |
| ACUTE RESPIRATORY FAILURE | 3 |
| ASTHENIA | 3 |
| DIARRHOEA | 3 |
| FATIGUE | 3 |
| INFECTION | 3 |
| TOXICITY TO VARIOUS AGENTS | 3 |
| WOUND | 3 |
| ACUTE KIDNEY INJURY | 2 |
| ACUTE MYELOID LEUKAEMIA | 2 |
Reactions in Hospitalization Reports
Top reactions in 370 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| SWELLING FACE | 35 |
| PAIN | 34 |
| HYPERSENSITIVITY | 26 |
| DYSPNOEA | 25 |
| PRURITUS | 23 |
| NAUSEA | 21 |
| FATIGUE | 20 |
| ANXIETY | 19 |
| DIARRHOEA | 18 |
| ERYTHEMA | 17 |
| RASH | 17 |
| EYE SWELLING | 16 |
| PNEUMONIA | 16 |
| CHEST PAIN | 15 |
| HEADACHE | 15 |
| VOMITING | 15 |
| ACUTE RESPIRATORY FAILURE | 14 |
Nearby, Related Medications
What the FAERS Data Reveals About benzoyl peroxide Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 6,624 voluntary reports linked to benzoyl peroxide and its brand equivalents (Benzac, PanOxyl), spanning 2004 through 2025. Of those, 51 (0.8%) listed death as an outcome and 370 (5.6%) involved hospitalization. The most common indication reported alongside adverse events was Acne.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 77% were female and 23% male; age distribution skews toward 18-44, with 1,995 reports in that bracket. The single most reported reaction is dry skin with 1,504 submissions, followed by acne and erythema.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to benzoyl peroxide's 6,624.
Read our methodology - how this data is sourced, computed, and verified.